U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pkn3 protein kinase N3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296619, updated on 14-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Pkn3provided by RGD
Official Full Name
protein kinase N3provided by RGD
Primary source
RGD:1305921
See related
EnsemblRapid:ENSRNOG00000025892 AllianceGenome:RGD:1305921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRRGT00147
Summary
Predicted to enable ATP binding activity; diacylglycerol-dependent serine/threonine kinase activity; and small GTPase binding activity. Predicted to be involved in epithelial cell migration. Orthologous to human PKN3 (protein kinase N3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 80.6), Spleen (RPKM 75.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pkn3 in Genome Data Viewer
Location:
3p12
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33747610..33761405)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13350082..13363572)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8628033..8656464)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene spectrin, alpha, non-erythrocytic 1 Neighboring gene dynein 2 intermediate chain 2 Neighboring gene Set nuclear proto-oncogene Neighboring gene zinc finger DHHC-type palmitoyltransferase 12 Neighboring gene zyg-11 related, cell cycle regulator Neighboring gene TBC1 domain family, member 13

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration. Lachmann S, et al. PLoS One, 2011. PMID 21754995, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium,diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine/threonine-protein kinase N3
NP_001376165.1
XP_006233834.1
XP_006233836.1
XP_008759862.1
XP_038960668.1
XP_038960670.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389236.1 → NP_001376165.1  serine/threonine-protein kinase N3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2JZ66, A0A8I5ZRC3, A6JTV0
    Related
    ENSRNOP00000070928.2, ENSRNOT00000077797.3
    Conserved Domains (5) summary
    cd11622
    Location:10 → 75
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    PHA03378
    Location:457 → 545
    PHA03378; EBNA-3B; Provisional
    cl00087
    Location:91 → 164
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:322 → 409
    C2; C2 domain
    cl21453
    Location:549 → 873
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    33747610..33761405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104742.2 → XP_038960670.1  serine/threonine-protein kinase N3 isoform X4

    Conserved Domains (4) summary
    cd11622
    Location:14 → 79
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    PHA03378
    Location:461 → 560
    PHA03378; EBNA-3B; Provisional
    cl00087
    Location:95 → 168
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:326 → 413
    C2; C2 domain

  2. XM_039104740.2 → XP_038960668.1  serine/threonine-protein kinase N3 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZRC3
    Related
    ENSRNOP00000043911.4, ENSRNOT00000050528.5
    Conserved Domains (5) summary
    cd11622
    Location:14 → 79
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    PHA03378
    Location:413 → 501
    PHA03378; EBNA-3B; Provisional
    cl00087
    Location:95 → 168
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:326 → 362
    C2; C2 domain
    cl21453
    Location:505 → 829
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006233772.5 → XP_006233834.1  serine/threonine-protein kinase N3 isoform X1

    See identical proteins and their annotated locations for XP_006233834.1

    UniProtKB/TrEMBL
    A0A8I5ZRC3, A6JTU9
    Related
    ENSRNOP00000081137.2, ENSRNOT00000098135.2
    Conserved Domains (5) summary
    PTZ00263
    Location:549 → 873
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd11622
    Location:14 → 79
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cl00087
    Location:95 → 168
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:326 → 413
    C2; C2 domain
    cl21453
    Location:553 → 877
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006233774.5 → XP_006233836.1  serine/threonine-protein kinase N3 isoform X2

    See identical proteins and their annotated locations for XP_006233836.1

    UniProtKB/TrEMBL
    A0A8I5ZRC3
    Conserved Domains (5) summary
    PTZ00263
    Location:527 → 851
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd11622
    Location:2 → 57
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cl00087
    Location:73 → 146
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:304 → 391
    C2; C2 domain
    cl21453
    Location:531 → 855
    PKc_like; Protein Kinases, catalytic domain

  5. XM_008761640.4 → XP_008759862.1  serine/threonine-protein kinase N3 isoform X2

    See identical proteins and their annotated locations for XP_008759862.1

    UniProtKB/TrEMBL
    A0A8I5ZRC3
    Conserved Domains (5) summary
    PTZ00263
    Location:527 → 851
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd11622
    Location:2 → 57
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cl00087
    Location:73 → 146
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:304 → 391
    C2; C2 domain
    cl21453
    Location:531 → 855
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_005501842.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001047861.1: Suppressed sequence

    Description
    NM_001047861.1: This RefSeq was removed because it is based on a transcript that represents a readthrough event with an upstream gene.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools