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Mapkap1 MAPK associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296648, updated on 2-Nov-2024

Summary

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Symbol
Mapkap1provided by RGD
Full Name
MAPK associated protein 1provided by RGD
Primary source
RGD:1305363
See related
EnsemblRapid:ENSRNOG00000017583 AllianceGenome:RGD:1305363
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including enzyme binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including TORC2 signaling; negative regulation of Ras protein signal transduction; and substantia nigra development. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of TORC2 complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human MAPKAP1 (MAPK associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 156.7), Thymus (RPKM 153.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mapkap1 in Genome Data Viewer
Location:
3p11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (38113268..38315913)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (17715813..17918387)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (13484952..13701772)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350352 Neighboring gene PBX homeobox 3 Neighboring gene uncharacterized LOC103691768 Neighboring gene uncharacterized LOC108350353 Neighboring gene ribosomal protein S7, pseudogene 1 Neighboring gene GTPase activating protein and VPS9 domains 1 Neighboring gene heat shock protein family A (Hsp70) member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. Schroder WA, et al. Cell Signal, 2007 Jun. PMID 17303383
  2. A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2. Murata H, et al. J Biol Chem, 2011 Mar 4. PMID 21177249, Free PMC Article
  3. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Jacinto E, et al. Cell, 2006 Oct 6. PMID 16962653
  4. Molecular mechanisms of mTOR-mediated translational control. Ma XM, et al. Nat Rev Mol Cell Biol, 2009 May. PMID 19339977
  5. mTOR signaling in growth control and disease. Laplante M, et al. Cell, 2012 Apr 13. PMID 22500797, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
  
part_of TORC2 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
target of rapamycin complex 2 subunit MAPKAP1
Names
SAPK-interacting protein 1
TORC2 subunit MAPKAP1
mitogen-activated protein kinase 2-associated protein 1
mitogen-activated protein kinase associated protein 1
stress-activated map kinase-interacting protein 1
target of rapamycin complex 2 subunit MAPKAP1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011964.1 → NP_001011964.1  target of rapamycin complex 2 subunit MAPKAP1

    See identical proteins and their annotated locations for NP_001011964.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079073
    UniProtKB/Swiss-Prot
    Q6AYF1
    Related
    ENSRNOP00000078499.2, ENSRNOT00000119554.2
    Conserved Domains (3) summary
    cd13331
    Location:383 → 490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18 → 129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:140 → 266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    38113268..38315913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104765.2 → XP_038960693.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYF1
    Conserved Domains (3) summary
    cd13331
    Location:383 → 490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18 → 129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:140 → 266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

  2. XM_063283509.1 → XP_063139579.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AEY0

  3. XM_063283505.1 → XP_063139575.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYF1

  4. XM_063283510.1 → XP_063139580.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AEY0

  5. XM_006233950.4 → XP_006234012.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

    See identical proteins and their annotated locations for XP_006234012.1

    UniProtKB/Swiss-Prot
    Q6AYF1
    Conserved Domains (3) summary
    cd13331
    Location:383 → 490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18 → 129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:140 → 266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

  6. XM_063283506.1 → XP_063139576.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYF1

  7. XM_006233949.4 → XP_006234011.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

    See identical proteins and their annotated locations for XP_006234011.1

    UniProtKB/Swiss-Prot
    Q6AYF1
    Related
    ENSRNOP00000102274.1, ENSRNOT00000139203.1
    Conserved Domains (3) summary
    cd13331
    Location:383 → 490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18 → 129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:140 → 266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

  8. XM_063283508.1 → XP_063139578.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AEY0
    Related
    ENSRNOP00000091071.1, ENSRNOT00000116389.2

  9. XM_063283511.1 → XP_063139581.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

    UniProtKB/TrEMBL
    A0A8L2QCJ2
    Related
    ENSRNOP00000102771.1, ENSRNOT00000125836.1

  10. XM_039104766.2 → XP_038960694.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AEY0
    Conserved Domains (3) summary
    cd13331
    Location:347 → 454
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18 → 129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:140 → 266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

  11. XM_039104768.2 → XP_038960696.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

    Conserved Domains (2) summary
    cd13331
    Location:191 → 298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:1 → 74
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

  12. XM_008761721.3 → XP_008759943.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

    See identical proteins and their annotated locations for XP_008759943.1

    Conserved Domains (2) summary
    cd13331
    Location:191 → 298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:1 → 74
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

  13. XM_008761722.3 → XP_008759944.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

    See identical proteins and their annotated locations for XP_008759944.1

    Conserved Domains (2) summary
    cd13331
    Location:191 → 298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:1 → 74
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

  14. XM_017591656.3 → XP_017447145.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

    Conserved Domains (2) summary
    cd13331
    Location:191 → 298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:1 → 74
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

  15. XM_017591654.3 → XP_017447143.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

    Conserved Domains (2) summary
    cd13331
    Location:191 → 298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:1 → 74
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYF1.1 GenPept UniProtKB/Swiss-Prot:Q6AYF1

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