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Fastk Fas-activated serine/threonine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 296741, updated on 28-Oct-2024

Summary

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Official Symbol
Fastkprovided by RGD
Official Full Name
Fas-activated serine/threonine kinaseprovided by RGD
Primary source
RGD:1311601
See related
EnsemblRapid:ENSRNOG00000011667 AllianceGenome:RGD:1311601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity and protein serine/threonine kinase activity. Predicted to be involved in mitochondrial RNA processing; protein phosphorylation; and regulation of gene expression. Predicted to be located in mitochondrion and nuclear speck. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Orthologous to human FASTK (Fas activated serine/threonine kinase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Heart (RPKM 252.5), Muscle (RPKM 194.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fastk in Genome Data Viewer
Location:
4q11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11624697..11628769)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10732273..10736332)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7260521..7264590)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene uncharacterized LOC134486542 Neighboring gene transmembrane and ubiquitin-like domain containing 1 Neighboring gene solute carrier family 4 member 2 Neighboring gene cyclin-dependent kinase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. Simarro M, et al. Proc Natl Acad Sci U S A, 2007 Jul 3. PMID 17592127, Free PMC Article
  2. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. Tian Q, et al. J Exp Med, 1995 Sep 1. PMID 7544399, Free PMC Article
  3. Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing. Izquierdo JM, et al. J Biol Chem, 2007 Jan 19. PMID 17135269
  4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fas-activated serine/threonine kinase
NP_001358218.1
XP_006235956.1
XP_006235957.1
XP_017448427.1
XP_038963148.1
XP_038963151.1
XP_063141764.1
XP_063141765.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371289.1 → NP_001358218.1  fas-activated serine/threonine kinase

    Status: VALIDATED

    Source sequence(s)
    BC083715, JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6A5X4
    Related
    ENSRNOP00000086402.1, ENSRNOT00000093879.2
    Conserved Domains (3) summary
    smart00952
    Location:480 → 532
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:274 → 339
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:352 → 439
    FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    11624697..11628769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107220.2 → XP_038963148.1  fas-activated serine/threonine kinase isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5X4
    Related
    ENSRNOP00000106571.1, ENSRNOT00000122749.1
    Conserved Domains (3) summary
    smart00952
    Location:452 → 504
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:246 → 311
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:324 → 411
    FAST_2; FAST kinase-like protein, subdomain 2

  2. XM_063285695.1 → XP_063141765.1  fas-activated serine/threonine kinase isoform X4

  3. XM_006235894.5 → XP_006235956.1  fas-activated serine/threonine kinase isoform X2

    See identical proteins and their annotated locations for XP_006235956.1

    UniProtKB/TrEMBL
    A0A8I6A5X4, A0A8I6AQA7, A6K549
    Related
    ENSRNOP00000096270.2, ENSRNOT00000107208.2
    Conserved Domains (3) summary
    smart00952
    Location:446 → 498
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:240 → 305
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:318 → 405
    FAST_2; FAST kinase-like protein, subdomain 2

  4. XM_006235895.4 → XP_006235957.1  fas-activated serine/threonine kinase isoform X2

    See identical proteins and their annotated locations for XP_006235957.1

    UniProtKB/TrEMBL
    A0A8I6A5X4, A0A8I6AQA7, A6K549
    Conserved Domains (3) summary
    smart00952
    Location:446 → 498
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:240 → 305
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:318 → 405
    FAST_2; FAST kinase-like protein, subdomain 2

  5. XM_017592938.3 → XP_017448427.1  fas-activated serine/threonine kinase isoform X2

    UniProtKB/TrEMBL
    A0A8I6A5X4, A0A8I6AQA7, A6K549
    Conserved Domains (3) summary
    smart00952
    Location:446 → 498
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:240 → 305
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:318 → 405
    FAST_2; FAST kinase-like protein, subdomain 2

  6. XM_063285694.1 → XP_063141764.1  fas-activated serine/threonine kinase isoform X3

  7. XM_039107223.2 → XP_038963151.1  fas-activated serine/threonine kinase isoform X5

    Conserved Domains (3) summary
    smart00952
    Location:245 → 297
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:39 → 104
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:117 → 204
    FAST_2; FAST kinase-like protein, subdomain 2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001011967.1: Suppressed sequence

    Description
    NM_001011967.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from zebrafish: fastk (GeneID:564534).
Nucleotide Protein Strain
Heading Accession and Version

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