Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp11a1provided by RGD
Official Full Name: cytochrome P450, family 11, subfamily a, polypeptide 1provided by RGD
Primary source: RGD:69325
See related: EnsemblRapid:ENSRNOG00000008074 AllianceGenome:RGD:69325
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp11a; Cypxia1; P450scc; P450(scc)
Summary: Predicted to enable cholesterol monooxygenase (side-chain-cleaving) activity and heme binding activity. Involved in several processes, including cellular response to cytokine stimulus; nervous system development; and steroid biosynthetic process. Located in mitochondrial crista and perikaryon. Biomarker of several diseases, including glucose metabolism disease (multiple); hypertension; nephrosis; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 27876.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (67318665..67330196)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (58422807..58434342)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (62798317..62809848)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR transcripts in C2C12 myoblasts.
Title: DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR transcripts in C2C12 myoblasts.
Gonadal sex steroid hormone secretion after exposure of male rats to estrogenic chemicals and their combinations.
Title: Gonadal sex steroid hormone secretion after exposure of male rats to estrogenic chemicals and their combinations.
Flutamide treatment reveals a relationship between steroidogenic activity of Leydig cells and ultrastructure of their mitochondria.
Title: Flutamide treatment reveals a relationship between steroidogenic activity of Leydig cells and ultrastructure of their mitochondria.
these steroidogenic enzymes within the Leydig cells, including steroidogenic acute regulatory protein (StAR), cholesterol side-chain cleavage cytochrome P450 (P450scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD), were down-regulated.
Title: HC diet inhibited testosterone synthesis by activating endoplasmic reticulum stress in testicular Leydig cells.
epigenetic changes such as histone modifications and chromatin remodeling occurred in the promoter region in granulosa cellss undergoing luteinization during ovulation
Title: Epigenetic Changes of the Cyp11a1 Promoter Region in Granulosa Cells Undergoing Luteinization During Ovulation in Female Rats.
In vivod-Asp administration induced serum LH release, causing indirect increase of androstenedione and testosterone levels by enhancing StAR, cytochrome P450 cholesterol side-chain cleavage enzyme and 3beta-hydroxysteroid dehydrogenase isomerases mRNA levels
Title: Stimulation of androgen production by D-aspartate through the enhancement of StAR, P450scc and 3β-HSD mRNA levels in vivo rat testis and in culture of immature rat Leydig cells.
These results suggest that P450scc overexpression and the resultant increase of 3alpha,5alpha-THP-positive cells in the ventral tegmental area reduces ethanol reinforcement.
Title: Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α,5α-THP and reduces long-term operant ethanol self-administration.
Leptin, which inhibits the ovulatory process, caused a significant reduction in the ovarian expression of P450scc without changes in StAR or 3betaHSD.
Title: Different levels of leptin regulate different target enzymes involved in progesterone synthesis.
Data from a rat model of polycystic ovary syndrome suggest that hyperandrogenism develops and this may partially up-regulate expression of steroidogenic enzymes (P450scc and CYP17 [cytochrome P450 family 17]) in ovarian tissue.
Title: Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS.
Atrazine induced alterations in the mRNA transcript copy numbers of steroidogenesis genes: steroidogenic acute regulatory protein, CYP11A1 and 3beta-hydroxysteroid dehydrogenase were shifted toward the control values by kolaviron.
Title: Kolaviron biflavanoids of Garcinia kola seeds protect atrazine-induced cytotoxicity in primary cultures of rat Leydig cells.

Submit: New GeneRIF Correction See all GeneRIFs (30)

General gene information

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Markers

PMC27916P1 (e-PCR)
- UniSTS:272390

UniSTS:464661 (e-PCR)
- UniSTS:464661

Cyp11a1 (e-PCR), detects polymorphism
- UniSTS:464661

RH134353 (e-PCR)
- UniSTS:217635

UniSTS:257092 (e-PCR)
- UniSTS:257092

Cyp11a1 (e-PCR), detects polymorphism
- UniSTS:257092

UniSTS:474701 (e-PCR)
- UniSTS:474701

Cyp11a1 (e-PCR), detects polymorphism
- UniSTS:474701

Cyp11a1 (e-PCR), detects polymorphism
- UniSTS:256604

PMC140651P2 (e-PCR)
- UniSTS:270947

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cholesterol monooxygenase (side-chain-cleaving) activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol monooxygenase (side-chain-cleaving) activity	IEA Inferred from Electronic Annotation more info
enables cholesterol monooxygenase (side-chain-cleaving) activity	ISO Inferred from Sequence Orthology more info
enables cholesterol monooxygenase (side-chain-cleaving) activity	TAS Traceable Author Statement more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in C21-steroid hormone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in C21-steroid hormone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in C21-steroid hormone biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within C21-steroid hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in C21-steroid hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in C21-steroid hormone metabolic process	IEA Inferred from Electronic Annotation more info
involved_in Leydig cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in Schwann cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in biphenyl metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to antibiotic	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to follicle-stimulating hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to gonadotropin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to peptide hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to peptide hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cortisol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dibenzo-p-dioxin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucocorticoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in granulosa cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hormone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organic acid metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in phenol-containing compound metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in phthalate metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to L-ascorbic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to alkaloid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fungicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gamma radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to genistein	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to insecticide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ionizing radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in steroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in testosterone biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial crista	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cholesterol side-chain cleavage enzyme, mitochondrial

Names: cholesterol desmolase; cholesterol side-chain cleavage cytochrome P450; cytochrome P450 11A1; cytochrome P450 11a cholesterol side chain cleavage; cytochrome P450 family 11 subfamily a; cytochrome P450 side-chain cleavage enzyme; cytochrome P450 subfamily 11A; cytochrome P450(scc)

NP_058982.1

EC 1.14.15.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.