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Iqub IQ motif and ubiquitin domain containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 296936, updated on 2-Nov-2024

Summary

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Official Symbol
Iqubprovided by RGD
Official Full Name
IQ motif and ubiquitin domain containingprovided by RGD
Primary source
RGD:4145674
See related
EnsemblRapid:ENSRNOG00000021729 AllianceGenome:RGD:4145674
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Trs4; RGD1562359
Summary
Predicted to be involved in cilium assembly; flagellated sperm motility; and mating. Predicted to act upstream of or within smoothened signaling pathway. Predicted to be located in sperm flagellum. Predicted to be part of radial spoke. Predicted to be active in acrosomal vesicle and motile cilium. Orthologous to human IQUB (IQ motif and ubiquitin domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 251.2), Heart (RPKM 49.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Iqub in Genome Data Viewer
Location:
4q22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (53897336..53962279, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (52931768..52993795, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (51482169..51586881, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 13 member 1 Neighboring gene thyroid hormone receptor associated protein 3, pseudogene 3 Neighboring gene inosine monophosphate dehydrogenase 2, pseudogene 1 Neighboring gene uncharacterized LOC108350676 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 Neighboring gene ankyrin repeat and SOCS box containing 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An NGF-induced Exo70-TC10 complex locally antagonises Cdc42-mediated activation of N-WASP to modulate neurite outgrowth. Pommereit D, et al. J Cell Sci, 2007 Aug 1. PMID 17635999
  2. Sorting nexin 9 interacts with dynamin 1 and N-WASP and coordinates synaptic vesicle endocytosis. Shin N, et al. J Biol Chem, 2007 Sep 28. PMID 17681954
  3. Identification of N-WASP homologs in human and rat brain. Fukuoka M, et al. Gene, 1997 Sep 1. PMID 9322739
  4. Male germ cell-specific protein Trs4 binds to multiple proteins. Shi YQ, et al. Biochem Biophys Res Commun, 2009 Oct 23. PMID 19706271
  5. Functional characterization of putative cilia genes by high-content analysis. Lai CK, et al. Mol Biol Cell, 2011 Apr. PMID 21289087, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggested that Trs4 might be involved in diverse processes of spermiogenesis and/or fertilization through interactions with its multiple binding partners.
    Title: Male germ cell-specific protein Trs4 binds to multiple proteins.
  2. findings confirm that the Exo70-TC10 complex mainly targets the NGF-induced Cdc42-dependent activation of N-WASP
    Title: An NGF-induced Exo70-TC10 complex locally antagonises Cdc42-mediated activation of N-WASP to modulate neurite outgrowth.
  3. SNX9 interacts with dynamin-1 and N-WASP in presynaptic terminals, where it links actin dynamics and synaptic vesicle endocytosis.
    Title: Sorting nexin 9 interacts with dynamin 1 and N-WASP and coordinates synaptic vesicle endocytosis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC116166

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mating ISO
Inferred from Sequence Orthology
more info
  
involved_in mating ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in 9+2 motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in 9+2 motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
part_of radial spoke ISO
Inferred from Sequence Orthology
more info
  
part_of radial spoke ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
IQ motif and ubiquitin-like domain-containing protein; IQ and ubiquitin-like domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034130.1 → NP_001029302.1  IQ motif and ubiquitin-like domain-containing protein

    See identical proteins and their annotated locations for NP_001029302.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099086
    UniProtKB/Swiss-Prot
    Q45GW3, Q4FZV4
    Related
    ENSRNOP00000063053.2, ENSRNOT00000064983.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    53897336..53962279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107272.2 → XP_038963200.1  IQ and ubiquitin-like domain-containing protein isoform X1

    Conserved Domains (1) summary
    cl28922
    Location:1 → 62
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_039107274.2 → XP_038963202.1  IQ and ubiquitin-like domain-containing protein isoform X2

  3. XM_063285735.1 → XP_063141805.1  IQ and ubiquitin-like domain-containing protein isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q45GW3.2 GenPept UniProtKB/Swiss-Prot:Q45GW3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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