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Hivep2 HIVEP zinc finger 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29721, updated on 2-Nov-2024

Summary

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Official Symbol
Hivep2provided by RGD
Official Full Name
HIVEP zinc finger 2provided by RGD
Primary source
RGD:61988
See related
EnsemblRapid:ENSRNOG00000011015 AllianceGenome:RGD:61988
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MIBP1
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 43. Orthologous to human HIVEP2 (HIVEP zinc finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 142.9), Thymus (RPKM 109.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hivep2 in Genome Data Viewer
Location:
1p13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (10176880..10376089)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (8358205..8555993)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (8129354..8333890)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cofilin 1, pseudogene 8 Neighboring gene uncharacterized LOC134484948 Neighboring gene androgen-induced 1 Neighboring gene ribosomal protein L13A, pseudogene 9 Neighboring gene transfer RNA alanine (anticodon AGC) 27 Neighboring gene similar to human chromosome 3 open reading frame 38

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a c-myc intron binding protein (MIBP1). Makino R, et al. Nucleic Acids Res, 1994 Dec 25. PMID 7838722, Free PMC Article
  2. Angiotensinogen gene-inducible enhancer-binding protein 1, a member of a new family of large nuclear proteins that recognize nuclear factor kappa B-binding sites through a zinc finger motif. Ron D, et al. Mol Cell Biol, 1991 May. PMID 2017183, Free PMC Article
  3. Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain. Dörflinger U, et al. Mol Cell Biol, 1999 May. PMID 10207097, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
human immunodeficiency virus type I enhancer-binding protein 2 homolog
Names
DNA-binding protein AGIE-BP1
MIBP-1
angiotensinogen gene-inducible enhancer-binding protein 1
c-myc intron binding protein 1
human immunodeficiency virus type 1 enhancer-binding protein 2
human immunodeficiency virus type I enhancer binding protein 2
myc intron-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024137.1 → NP_077051.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog

    See identical proteins and their annotated locations for NP_077051.1

    Status: PROVISIONAL

    Source sequence(s)
    D37951
    UniProtKB/Swiss-Prot
    Q00900, Q63725
    Related
    ENSRNOP00000015131.2, ENSRNOT00000015131.6
    Conserved Domains (5) summary
    sd00017
    Location:191 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1792 → 1812
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1843 → 1877
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1790 → 1812
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:204 → 228
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    10176880..10376089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109867.2 → XP_038965795.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A6JP69, G3V7H8
    Conserved Domains (8) summary
    PTZ00449
    Location:2024 → 2167
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PTZ00441
    Location:824 → 935
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00017
    Location:191 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1792 → 1812
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1843 → 1877
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1790 → 1812
    zf-C2H2; Zinc finger, C2H2 type
    pfam12171
    Location:1818 → 1842
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:204 → 228
    zf-H2C2_2; Zinc-finger double domain

  2. XM_063287903.1 → XP_063143973.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A6JP69, G3V7H8

  3. XM_039109863.2 → XP_038965791.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A6JP69, G3V7H8
    Conserved Domains (8) summary
    PTZ00449
    Location:2024 → 2167
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PTZ00441
    Location:824 → 935
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00017
    Location:191 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1792 → 1812
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1843 → 1877
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1790 → 1812
    zf-C2H2; Zinc finger, C2H2 type
    pfam12171
    Location:1818 → 1842
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:204 → 228
    zf-H2C2_2; Zinc-finger double domain

  4. XM_039109870.2 → XP_038965798.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A6JP69, G3V7H8
    Conserved Domains (8) summary
    PTZ00449
    Location:2024 → 2167
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PTZ00441
    Location:824 → 935
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00017
    Location:191 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1792 → 1812
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1843 → 1877
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1790 → 1812
    zf-C2H2; Zinc finger, C2H2 type
    pfam12171
    Location:1818 → 1842
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:204 → 228
    zf-H2C2_2; Zinc-finger double domain

  5. XM_039109882.2 → XP_038965810.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A6JP69, G3V7H8
    Conserved Domains (8) summary
    PTZ00449
    Location:2024 → 2167
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PTZ00441
    Location:824 → 935
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00017
    Location:191 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1792 → 1812
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1843 → 1877
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1790 → 1812
    zf-C2H2; Zinc finger, C2H2 type
    pfam12171
    Location:1818 → 1842
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:204 → 228
    zf-H2C2_2; Zinc-finger double domain

  6. XM_039109890.2 → XP_038965818.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A6JP69, G3V7H8
    Conserved Domains (8) summary
    PTZ00449
    Location:2024 → 2167
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PTZ00441
    Location:824 → 935
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00017
    Location:191 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1792 → 1812
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1843 → 1877
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1790 → 1812
    zf-C2H2; Zinc finger, C2H2 type
    pfam12171
    Location:1818 → 1842
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:204 → 228
    zf-H2C2_2; Zinc-finger double domain

  7. XM_039109872.2 → XP_038965800.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A6JP69, G3V7H8
    Conserved Domains (8) summary
    PTZ00449
    Location:2024 → 2167
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PTZ00441
    Location:824 → 935
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00017
    Location:191 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1792 → 1812
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1843 → 1877
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1790 → 1812
    zf-C2H2; Zinc finger, C2H2 type
    pfam12171
    Location:1818 → 1842
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:204 → 228
    zf-H2C2_2; Zinc-finger double domain

  8. XM_063287906.1 → XP_063143976.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A6JP69, G3V7H8

  9. XM_039109885.2 → XP_038965813.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A6JP69, G3V7H8
    Conserved Domains (8) summary
    PTZ00449
    Location:2024 → 2167
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PTZ00441
    Location:824 → 935
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00017
    Location:191 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1792 → 1812
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1843 → 1877
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1790 → 1812
    zf-C2H2; Zinc finger, C2H2 type
    pfam12171
    Location:1818 → 1842
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:204 → 228
    zf-H2C2_2; Zinc-finger double domain

  10. XM_063287884.1 → XP_063143954.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A6JP69, G3V7H8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00900.2 GenPept UniProtKB/Swiss-Prot:Q00900

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