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Tprkb Tp53rk binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 297411, updated on 10-Oct-2024

Summary

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Symbol
Tprkbprovided by RGD
Full Name
Tp53rk binding proteinprovided by RGD
Primary source
RGD:1309786
See related
EnsemblRapid:ENSRNOG00000050645 AllianceGenome:RGD:1309786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cgi-121; RGD1309786
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification and telomere maintenance via recombination. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 5. Orthologous to human TPRKB (TP53RK binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 167.9), Adrenal (RPKM 84.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tprkb in Genome Data Viewer
Location:
4q34
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (119900374..119915374)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (118342910..118357908)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (117589527..117604481)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 4 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 1 Neighboring gene N-acetyltransferase 8B Neighboring gene dual specificity phosphatase 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein. Miyoshi A, et al. Biochem Biophys Res Commun, 2003 Apr 4. PMID 12659830
  2. Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7. Wan LC, et al. Nucleic Acids Res, 2017 Jan 25. PMID 27903914, Free PMC Article
  3. Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Braun DA, et al. Nat Genet, 2017 Oct. PMID 28805828, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA threonylcarbamoyladenosine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA threonylcarbamoyladenosine modification ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA threonylcarbamoyladenosine modification ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of EKC/KEOPS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EKC/KEOPS complex ISO
Inferred from Sequence Orthology
more info
  
part_of EKC/KEOPS complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
EKC/KEOPS complex subunit Tprkb
Names
PRPK-binding protein
Prpk (p53-related protein kinase)-binding protein
TP53RK-binding protein
TP53RK-binding protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013926.3 → NP_001013948.2  EKC/KEOPS complex subunit Tprkb

    See identical proteins and their annotated locations for NP_001013948.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q5PQR8
    UniProtKB/TrEMBL
    A6IAU0, A6IAU1, G3V805
    Conserved Domains (1) summary
    pfam08617
    Location:20 → 172
    CGI-121; Kinase binding protein CGI-121

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    119900374..119915374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107360.2 → XP_038963288.1  EKC/KEOPS complex subunit Tprkb isoform X1

    UniProtKB/Swiss-Prot
    Q5PQR8
    UniProtKB/TrEMBL
    A6IAU0, A6IAU1, G3V805
    Conserved Domains (1) summary
    pfam08617
    Location:20 → 172
    CGI-121; Kinase binding protein CGI-121

  2. XM_006236746.5 → XP_006236808.1  EKC/KEOPS complex subunit Tprkb isoform X1

    See identical proteins and their annotated locations for XP_006236808.1

    UniProtKB/Swiss-Prot
    Q5PQR8
    UniProtKB/TrEMBL
    A6IAU0, A6IAU1, G3V805
    Conserved Domains (1) summary
    pfam08617
    Location:20 → 172
    CGI-121; Kinase binding protein CGI-121

  3. XM_063285808.1 → XP_063141878.1  EKC/KEOPS complex subunit Tprkb isoform X1

    UniProtKB/TrEMBL
    A6IAU0, G3V805
    Related
    ENSRNOP00000066993.3, ENSRNOT00000074924.4

  4. XM_063285810.1 → XP_063141880.1  EKC/KEOPS complex subunit Tprkb isoform X1

    UniProtKB/TrEMBL
    A6IAU0, G3V805

  5. XM_063285809.1 → XP_063141879.1  EKC/KEOPS complex subunit Tprkb isoform X1

    UniProtKB/TrEMBL
    A6IAU0, G3V805

  6. XM_017593013.3 → XP_017448502.1  EKC/KEOPS complex subunit Tprkb isoform X1

    UniProtKB/Swiss-Prot
    Q5PQR8
    UniProtKB/TrEMBL
    A6IAU0, A6IAU1, G3V805
    Conserved Domains (1) summary
    pfam08617
    Location:20 → 172
    CGI-121; Kinase binding protein CGI-121

  7. XM_006236743.5 → XP_006236805.1  EKC/KEOPS complex subunit Tprkb isoform X1

    See identical proteins and their annotated locations for XP_006236805.1

    UniProtKB/Swiss-Prot
    Q5PQR8
    UniProtKB/TrEMBL
    A6IAU0, A6IAU1, G3V805
    Conserved Domains (1) summary
    pfam08617
    Location:20 → 172
    CGI-121; Kinase binding protein CGI-121

  8. XM_039107356.2 → XP_038963284.1  EKC/KEOPS complex subunit Tprkb isoform X1

    UniProtKB/Swiss-Prot
    Q5PQR8
    UniProtKB/TrEMBL
    A6IAU0, A6IAU1, G3V805
    Related
    ENSRNOP00000021211.3, ENSRNOT00000021211.8
    Conserved Domains (1) summary
    pfam08617
    Location:20 → 172
    CGI-121; Kinase binding protein CGI-121

  9. XM_039107357.2 → XP_038963285.1  EKC/KEOPS complex subunit Tprkb isoform X1

    UniProtKB/Swiss-Prot
    Q5PQR8
    UniProtKB/TrEMBL
    A6IAU0, A6IAU1, G3V805
    Conserved Domains (1) summary
    pfam08617
    Location:20 → 172
    CGI-121; Kinase binding protein CGI-121

  10. XM_039107359.2 → XP_038963287.1  EKC/KEOPS complex subunit Tprkb isoform X1

    UniProtKB/Swiss-Prot
    Q5PQR8
    UniProtKB/TrEMBL
    A6IAU0, A6IAU1, G3V805
    Conserved Domains (1) summary
    pfam08617
    Location:20 → 172
    CGI-121; Kinase binding protein CGI-121
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQR8.1 GenPept UniProtKB/Swiss-Prot:Q5PQR8

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