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Abtb1 ankyrin repeat and BTB domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297432, updated on 28-Oct-2024

Summary

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Official Symbol
Abtb1provided by RGD
Official Full Name
ankyrin repeat and BTB domain containing 1provided by RGD
Primary source
RGD:1359363
See related
EnsemblRapid:ENSRNOG00000015762 AllianceGenome:RGD:1359363
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human ABTB1 (ankyrin repeat and BTB domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Spleen (RPKM 156.4), Muscle (RPKM 107.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Abtb1 in Genome Data Viewer
Location:
4q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (122856558..122862895, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (121299302..121305667, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (120778580..120784807, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486810 Neighboring gene monoglyceride lipase Neighboring gene transfer RNA valine (anticodon AAC) 19 Neighboring gene podocalyxin-like 2 Neighboring gene minichromosome maintenance complex component 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Unoki M, et al. Oncogene, 2001 Jul 27. PMID 11494141
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94157

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ankyrin repeat and BTB/POZ domain-containing protein 1
Names
ankyrin repeat and BTB (POZ) domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005902.1 → NP_001005902.1  ankyrin repeat and BTB/POZ domain-containing protein 1

    See identical proteins and their annotated locations for NP_001005902.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083579
    UniProtKB/Swiss-Prot
    Q5XIU1
    UniProtKB/TrEMBL
    A0A8I6AFV2, A6IB50
    Related
    ENSRNOP00000087062.1, ENSRNOT00000119739.2
    Conserved Domains (5) summary
    sd00045
    Location:35 → 60
    ANK; ANK repeat [structural motif]
    cd18295
    Location:97 → 214
    BTB1_POZ_ABTB1_BPOZ1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)
    cd18296
    Location:254 → 377
    BTB2_POZ_ABTB1_BPOZ1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)
    cd18497
    Location:376 → 447
    BACK_ABTB1_BPOZ; BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)
    pfam12796
    Location:6 → 65
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    122856558..122862895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107368.2 → XP_038963296.1  ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AFV2, A0A8L2QB88
    Related
    ENSRNOP00000021445.5, ENSRNOT00000021445.7
    Conserved Domains (3) summary
    cd18295
    Location:76 → 193
    BTB1_POZ_ABTB1_BPOZ1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)
    cd18296
    Location:233 → 356
    BTB2_POZ_ABTB1_BPOZ1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)
    cd18497
    Location:355 → 426
    BACK_ABTB1_BPOZ; BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

  2. XM_063285817.1 → XP_063141887.1  ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIU1.1 GenPept UniProtKB/Swiss-Prot:Q5XIU1

Gene LinkOut

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