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Fau FAU ubiquitin like and ribosomal protein S30 fusion [ Rattus norvegicus (Norway rat) ]

Gene ID: 29752, updated on 2-Nov-2024

Summary

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Official Symbol
Fauprovided by RGD
Official Full Name
FAU ubiquitin like and ribosomal protein S30 fusionprovided by RGD
Primary source
RGD:61938
See related
EnsemblRapid:ENSRNOG00000020982 AllianceGenome:RGD:61938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in several processes, including defense response to other organism; protein ubiquitination; and ribosomal small subunit assembly. Predicted to be located in cytosolic ribosome and extracellular space. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasm and nucleus. Orthologous to human FAU (FAU ubiquitin like and ribosomal protein S30 fusion). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 3349.7), Thymus (RPKM 2896.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fau in Genome Data Viewer
Location:
1q43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212779429..212781028)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203350226..203351741)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221420312..221421827)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene calpain 1 Neighboring gene uncharacterized LOC108349685 Neighboring gene synoviolin 1 Neighboring gene mitochondrial ribosomal protein L49 Neighboring gene zinc finger, HIT-type containing 2 Neighboring gene transmembrane 7 superfamily member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The carboxyl extension of a ubiquitin-like protein is rat ribosomal protein S30. Olvera J, et al. J Biol Chem, 1993 Aug 25. PMID 8394356
  2. Ubiquicidin, a novel murine microbicidal protein present in the cytosolic fraction of macrophages. Hiemstra PS, et al. J Leukoc Biol, 1999 Sep. PMID 10496312
  3. Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits. O'Donohue MF, et al. J Cell Biol, 2010 Sep 6. PMID 20819938, Free PMC Article
  4. Antimicrobial peptides in the first line defence of human colon mucosa. Tollin M, et al. Peptides, 2003 Apr. PMID 12860195
  5. Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes. Yu Y, et al. Protein Sci, 2005 Jun. PMID 15883184, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response in mucosa ISO
Inferred from Sequence Orthology
more info
  
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
40S ribosomal protein S30
Names
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived) protein
Finkel-Biskis-Reilly murine sarcoma virusubiquitously expressed
ribosomal protein S30
ubiquitin-like protein FUBI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012739.1 → NP_001012757.1  40S ribosomal protein S30 precursor

    See identical proteins and their annotated locations for NP_001012757.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC091402
    UniProtKB/TrEMBL
    A0A8I6A5S6, A0A9K3Y6P2, D4A7R8, Q5BJN7
    Related
    ENSRNOP00000028481.4, ENSRNOT00000028481.8
    Conserved Domains (2) summary
    cd01793
    Location:1 → 74
    Ubl_FUBI; ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins
    pfam04758
    Location:75 → 132
    Ribosomal_S30; Ribosomal protein S30

  2. NM_001160231.1 → NP_001153703.1  40S ribosomal protein S30 precursor

    See identical proteins and their annotated locations for NP_001153703.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC091402, CB316435
    UniProtKB/TrEMBL
    A0A8I6A5S6, A0A9K3Y6P2, D4A7R8, Q5BJN7
    Conserved Domains (2) summary
    cd01793
    Location:1 → 74
    Ubl_FUBI; ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins
    pfam04758
    Location:75 → 132
    Ribosomal_S30; Ribosomal protein S30

  3. NM_001160232.1 → NP_001153704.1  40S ribosomal protein S30 precursor

    See identical proteins and their annotated locations for NP_001153704.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC091402
    UniProtKB/TrEMBL
    A0A8I6A5S6, A0A9K3Y6P2, D4A7R8, Q5BJN7
    Conserved Domains (2) summary
    cd01793
    Location:1 → 74
    Ubl_FUBI; ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins
    pfam04758
    Location:75 → 132
    Ribosomal_S30; Ribosomal protein S30

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    212779429..212781028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287966.1 → XP_063144036.1  40S ribosomal protein S30 isoform X1

  2. XM_063287956.1 → XP_063144026.1  40S ribosomal protein S30 isoform X1

  3. XM_063287976.1 → XP_063144046.1  40S ribosomal protein S30 isoform X2

    UniProtKB/TrEMBL
    A0A9K3Y6P2, D4A7R8, Q5BJN7

  4. XM_063287968.1 → XP_063144038.1  40S ribosomal protein S30 isoform X1

  5. XM_063287971.1 → XP_063144041.1  40S ribosomal protein S30 isoform X1

  6. XM_063287978.1 → XP_063144048.1  40S ribosomal protein S30 isoform X2

    UniProtKB/TrEMBL
    A0A9K3Y6P2, D4A7R8, Q5BJN7

  7. XM_063287974.1 → XP_063144044.1  40S ribosomal protein S30 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62864.1 GenPept UniProtKB/Swiss-Prot:P62864
Q05474.1 GenPept UniProtKB/Swiss-Prot:Q05474

Gene LinkOut

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