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Rad52 RAD52 homolog, DNA repair protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 297561, updated on 28-Oct-2024

Summary

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Official Symbol
Rad52provided by RGD
Official Full Name
RAD52 homolog, DNA repair proteinprovided by RGD
Primary source
RGD:1304975
See related
EnsemblRapid:ENSRNOG00000009742 AllianceGenome:RGD:1304975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; double-strand break repair via single-strand annealing; and mitotic recombination. Predicted to act upstream of or within DNA double-strand break processing involved in repair via single-strand annealing; cellular response to oxidative stress; and regulation of nucleotide-excision repair. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung cancer (multiple); mucoepidermoid carcinoma; and nicotine dependence. Orthologous to human RAD52 (RAD52 homolog, DNA repair protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Spleen (RPKM 40.2), Thymus (RPKM 36.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rad52 in Genome Data Viewer
Location:
4q42
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (154778320..154802002)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (153106062..153128598)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (152429826..152451875)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene uncharacterized LOC120102377 Neighboring gene COMM domain containing 6-like Neighboring gene WNK lysine deficient protein kinase 1 Neighboring gene ribosomal protein S12 like 11 Neighboring gene ninjurin 2 Neighboring gene ribosomal protein L4, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evaluating the role of RAD52 and its interactors as novel potential molecular targets for hepatocellular carcinoma. Li P, et al. Cancer Cell Int, 2019. PMID 31719794, Free PMC Article
  2. RAD52 is required for RNA-templated recombination repair in post-mitotic neurons. Welty S, et al. J Biol Chem, 2018 Jan 26. PMID 29217771, Free PMC Article
  3. [Genetic variation in DNA repair gene RAD52 is associated with the response to platinum-based chemotherapy in SCLC patients]. Li HM, et al. Zhonghua Zhong Liu Za Zhi, 2016 Jul. PMID 27531263
  4. Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. Kazma R, et al. Carcinogenesis, 2012 May. PMID 22382497, Free PMC Article
  5. Identification of an SCLC susceptibility rs7963551 genetic polymorphism in a previously GWAS-identified 12p13.33 RAD52 lung cancer risk locus in the Chinese population. Han S, et al. Int J Clin Exp Med, 2015. PMID 26629180, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA double-strand break processing involved in repair via single-strand annealing ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA double-strand break processing involved in repair via single-strand annealing ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA recombinase assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via single-strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA repair protein RAD52 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354109.1 → NP_001341038.1  DNA repair protein RAD52 homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    154778320..154802002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763232.4 → XP_008761454.1  DNA repair protein RAD52 homolog isoform X1

    See identical proteins and their annotated locations for XP_008761454.1

    UniProtKB/TrEMBL
    D3ZZL1
    Related
    ENSRNOP00000013070.7, ENSRNOT00000013070.10
    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

  2. XM_008763237.4 → XP_008761459.1  DNA repair protein RAD52 homolog isoform X9

    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

  3. XM_039107433.2 → XP_038963361.1  DNA repair protein RAD52 homolog isoform X3

    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

  4. XM_039107434.2 → XP_038963362.1  DNA repair protein RAD52 homolog isoform X7

    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

  5. XM_063285895.1 → XP_063141965.1  DNA repair protein RAD52 homolog isoform X10

  6. XM_008763238.4 → XP_008761460.1  DNA repair protein RAD52 homolog isoform X11

    Related
    ENSRNOP00000073295.3, ENSRNOT00000084520.3
    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

  7. XM_063285896.1 → XP_063141966.1  DNA repair protein RAD52 homolog isoform X12

    UniProtKB/TrEMBL
    A0A0G2K552

  8. XM_008763234.4 → XP_008761456.1  DNA repair protein RAD52 homolog isoform X2

    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

  9. XM_063285893.1 → XP_063141963.1  DNA repair protein RAD52 homolog isoform X6

  10. XM_063285894.1 → XP_063141964.1  DNA repair protein RAD52 homolog isoform X8

  11. XM_017592585.3 → XP_017448074.1  DNA repair protein RAD52 homolog isoform X14

  12. XM_063285899.1 → XP_063141969.1  DNA repair protein RAD52 homolog isoform X15

  13. XM_063285901.1 → XP_063141971.1  DNA repair protein RAD52 homolog isoform X17

  14. XM_063285900.1 → XP_063141970.1  DNA repair protein RAD52 homolog isoform X16

  15. XM_008763235.4 → XP_008761457.1  DNA repair protein RAD52 homolog isoform X4

    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

  16. XM_008763233.4 → XP_008761455.1  DNA repair protein RAD52 homolog isoform X1

    See identical proteins and their annotated locations for XP_008761455.1

    UniProtKB/TrEMBL
    D3ZZL1
    Conserved Domains (1) summary
    TIGR00607
    Location:39 → 200
    rad52; recombination protein rad52

  17. XM_063285892.1 → XP_063141962.1  DNA repair protein RAD52 homolog isoform X5

  18. XM_063285897.1 → XP_063141967.1  DNA repair protein RAD52 homolog isoform X12

    UniProtKB/TrEMBL
    A0A0G2K552

  19. XM_063285898.1 → XP_063141968.1  DNA repair protein RAD52 homolog isoform X13

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106617.2: Suppressed sequence

    Description
    NM_001106617.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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