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Mug1l1 murinoglobulin 1 like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297568, updated on 18-Sep-2024

Summary

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Official Symbol
Mug1l1provided by RGD
Official Full Name
murinoglobulin 1 like 1provided by RGD
Primary source
RGD:1584999
See related
EnsemblRapid:ENSRNOG00000070375 AllianceGenome:RGD:1584999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
A1i3; alpha-1-I3
Summary
Predicted to enable endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular space. Orthologous to human PZP (PZP alpha-2-macroglobulin like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 13951.4) See more
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Genomic context

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See Mug1l1 in Genome Data Viewer
Location:
4q42
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (156652355..156708771)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (154980279..155036688)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (154505736..154565104)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene voltage-dependent anion channel 2, pseudogene 4 Neighboring gene alpha-2-macroglobulin Neighboring gene thymosin beta-10 pseudogene Neighboring gene salvador family WW domain containing protein 1, pseudogene 1 Neighboring gene murinoglobulin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure and negative transcriptional regulation by glucocorticoids of the acute-phase rat alpha 1-inhibitor III gene. Northemann W, et al. Biochemistry, 1989 Jan 10. PMID 2495816
  2. Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3. Enghild JJ, et al. J Biol Chem, 1989 Jul 5. PMID 2472396
  3. Sequence and acute phase regulation of rat alpha 1-inhibitor III messenger RNA. Braciak TA, et al. J Biol Chem, 1988 Mar 15. PMID 2831216
  4. Identification and sequencing of cDNA clones for the rodent negative acute-phase protein alpha 1-inhibitor 3. Schweizer M, et al. Eur J Biochem, 1987 Apr 15. PMID 2436907
  5. The sclerostin-bone protein interactome. Devarajan-Ketha H, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22206666, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1-inhibitor 3
Names
alpha-1-inhibitor III
murinoglobulin-2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037975.2 → NP_001033064.2  alpha-1-inhibitor 3 precursor

    See identical proteins and their annotated locations for NP_001033064.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P14046, Q4G042, Q63266, Q6LDP2, Q6LDR8
    UniProtKB/TrEMBL
    A0A0G2K926, A6ILD3
    Related
    ENSRNOP00000074833.2, ENSRNOT00000081488.3
    Conserved Domains (6) summary
    cd02897
    Location:961 → 1267
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:741 → 831
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129 → 221
    A2M_N; MG2 domain
    pfam07677
    Location:1379 → 1466
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:1014 → 1269
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:459 → 606
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    156652355..156708771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107437.2 → XP_038963365.1  alpha-1-inhibitor 3 isoform X1

    UniProtKB/Swiss-Prot
    P14046, Q4G042, Q63266, Q6LDP2, Q6LDR8
    Related
    ENSRNOP00000077625.1, ENSRNOT00000110576.2
    Conserved Domains (7) summary
    cd02897
    Location:961 → 1267
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:741 → 831
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129 → 221
    A2M_N; MG2 domain
    pfam07677
    Location:1379 → 1466
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:457 → 606
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:348 → 443
    MG4; Macroglobulin domain MG4
    pfam17791
    Location:223 → 309
    MG3; Macroglobulin domain MG3

  2. XM_039107439.2 → XP_038963367.1  alpha-1-inhibitor 3 isoform X2

    Conserved Domains (6) summary
    pfam00207
    Location:741 → 831
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129 → 221
    A2M_N; MG2 domain
    pfam07703
    Location:457 → 606
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam17789
    Location:348 → 443
    MG4; Macroglobulin domain MG4
    pfam17791
    Location:223 → 309
    MG3; Macroglobulin domain MG3
    cl08267
    Location:961 → 1125
    ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14046.1 GenPept UniProtKB/Swiss-Prot:P14046

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