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Erp27 endoplasmic reticulum protein 27 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297698, updated on 2-Nov-2024

Summary

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Official Symbol
Erp27provided by RGD
Official Full Name
endoplasmic reticulum protein 27provided by RGD
Primary source
RGD:1565381
See related
EnsemblRapid:ENSRNOG00000005787 AllianceGenome:RGD:1565381
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565381
Summary
Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Orthologous to human ERP27 (endoplasmic reticulum protein 27). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 108.5), Liver (RPKM 33.5) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Erp27 in Genome Data Viewer
Location:
4q43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (171535845..171552848, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (169804656..169821660, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (170893946..170912629, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 4 Neighboring gene matrix Gla protein Neighboring gene Rho GDP dissociation inhibitor beta Neighboring gene uncharacterized LOC134486856

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
endoplasmic reticulum resident protein 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106625.1 → NP_001100095.1  endoplasmic reticulum resident protein 27 precursor

    See identical proteins and their annotated locations for NP_001100095.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473964
    UniProtKB/TrEMBL
    A6IMJ4, D4A9L9
    Related
    ENSRNOP00000052551.3, ENSRNOT00000055691.4
    Conserved Domains (3) summary
    cd02981
    Location:43 → 139
    PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02982
    Location:156 → 253
    PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    pfam13848
    Location:64 → 250
    Thioredoxin_6; Thioredoxin-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    171535845..171552848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107460.2 → XP_038963388.1  endoplasmic reticulum resident protein 27 isoform X1

    Conserved Domains (1) summary
    pfam13848
    Location:1 → 174
    Thioredoxin_6; Thioredoxin-like domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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