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Aebp2 AE binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297705, updated on 13-Apr-2024

Summary

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Official Symbol
Aebp2provided by RGD
Official Full Name
AE binding protein 2provided by RGD
Primary source
RGD:1307233
See related
Ensembl:ENSRNOG00000008929 AllianceGenome:RGD:1307233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Predicted to be part of ESC/E(Z) complex. Orthologous to human AEBP2 (AE binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 93.3), Adrenal (RPKM 87.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aebp2 in Genome Data Viewer
Location:
4q44
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (175258286..175297149)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (173527881..173566033)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (174799378..174863260)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A5 Neighboring gene uncharacterized LOC134486859 Neighboring gene uncharacterized LOC120102424 Neighboring gene uncharacterized LOC134486860 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel zinc finger transcriptional repressor. A direct role of the zinc finger motif in repression. He GP, et al. J Biol Chem, 1999 May 21. PMID 10329662
  2. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Herz HM, et al. Trends Biochem Sci, 2013 Dec. PMID 24148750, Free PMC Article
  3. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Peng JC, et al. Cell, 2009 Dec 24. PMID 20064375, Free PMC Article
  4. EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells. Ragazzini R, et al. Nat Commun, 2019 Aug 26. PMID 31451685, Free PMC Article
  5. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Pasini D, et al. Nature, 2010 Mar 11. PMID 20075857

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein AEBP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401545.1 → NP_001388474.1  zinc finger protein AEBP2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AAA0
    Related
    ENSRNOP00000083013.1, ENSRNOT00000110876.1
    Conserved Domains (2) summary
    COG5048
    Location:209 → 356
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:258 → 278
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    175258286..175297149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107463.2 → XP_038963391.1  zinc finger protein AEBP2 isoform X3

    UniProtKB/TrEMBL
    A6IMN6, D3ZED3
    Related
    ENSRNOP00000036497.4
    Conserved Domains (2) summary
    COG5048
    Location:3 → 110
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:37 → 57
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_039107462.2 → XP_038963390.1  zinc finger protein AEBP2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AAA0
    Related
    ENSRNOP00000086613.1
    Conserved Domains (2) summary
    COG5048
    Location:209 → 356
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:258 → 278
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_039107461.2 → XP_038963389.1  zinc finger protein AEBP2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A054
    Related
    ENSRNOP00000083862.1
    Conserved Domains (3) summary
    COG5048
    Location:209 → 356
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:258 → 278
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:307 → 333
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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