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Dnai7 dynein axonemal intermediate chain 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297720, updated on 17-Aug-2024

Summary

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Official Symbol
Dnai7provided by RGD
Official Full Name
dynein axonemal intermediate chain 7provided by RGD
Primary source
RGD:1311213
See related
EnsemblRapid:ENSRNOG00000027630 AllianceGenome:RGD:1311213
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Las1; Casc1; Cfap94
Summary
Predicted to enable beta-tubulin binding activity and microtubule binding activity. Predicted to be located in cilium; cytoplasm; and microtubule cytoskeleton. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme. Orthologous to human DNAI7 (dynein axonemal intermediate chain 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 45.8), Testes (RPKM 39.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q44
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (179874338..179910716, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (178143499..178179871, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (179440984..179476965, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein uS10-like Neighboring gene branched chain amino acid transaminase 1 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene uncharacterized LOC134486864 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene KRAS proto-oncogene, GTPase Neighboring gene uncharacterized LOC134486865

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mechanisms promoting escape from mitotic stress-induced tumor cell death. Sinnott R, et al. Cancer Res, 2014 Jul 15. PMID 24860162, Free PMC Article
  2. Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression. Liu Y, et al. Cancer Res, 2007 Nov 1. PMID 17974961
  3. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Zhang Z, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14583591, Free PMC Article
  4. Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. Liu P, et al. Nat Genet, 2006 Aug. PMID 16862160
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of mouse Casc1 (Las1) as a candidate for lung cancer susceptibility, and comparison of the protein to the rat and human orthologs.
    Title: Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of axonemal dynein complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dynein axonemal intermediate chain 7
Names
cancer susceptibility 1
cancer susceptibility candidate 1
cilia and flagella associated protein 94
dynein intermediate chain CFAP94, axonemal
lung adenoma susceptibility 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106627.3 → NP_001100097.2  dynein axonemal intermediate chain 7

    See identical proteins and their annotated locations for NP_001100097.2

    Status: PROVISIONAL

    Source sequence(s)
    BC160907
    UniProtKB/TrEMBL
    A0A8I6ACC4, B1H288
    Related
    ENSRNOP00000035058.6, ENSRNOT00000030680.7
    Conserved Domains (2) summary
    pfam12366
    Location:244 → 469
    Casc1; Cancer susceptibility candidate 1
    pfam15927
    Location:37 → 229
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    179874338..179910716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107470.2 → XP_038963398.1  dynein axonemal intermediate chain 7 isoform X5

    UniProtKB/TrEMBL
    A0A8I6ACC4
    Conserved Domains (1) summary
    pfam15927
    Location:4 → 137
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  2. XM_039107474.2 → XP_038963402.1  dynein axonemal intermediate chain 7 isoform X6

    UniProtKB/TrEMBL
    A0A8I6ACC4
    Conserved Domains (1) summary
    pfam15927
    Location:1 → 136
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  3. XM_039107473.2 → XP_038963401.1  dynein axonemal intermediate chain 7 isoform X4

    UniProtKB/TrEMBL
    A0A8I6ACC4
    Conserved Domains (1) summary
    pfam15927
    Location:22 → 168
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  4. XM_039107467.2 → XP_038963395.1  dynein axonemal intermediate chain 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ACC4
    Conserved Domains (1) summary
    pfam15927
    Location:37 → 256
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  5. XM_039107476.2 → XP_038963404.1  dynein axonemal intermediate chain 7 isoform X8

    Conserved Domains (1) summary
    pfam15927
    Location:37 → 266
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  6. XM_039107466.2 → XP_038963394.1  dynein axonemal intermediate chain 7 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACC4, F7FKY0
    Conserved Domains (1) summary
    pfam15927
    Location:37 → 266
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  7. XM_039107475.2 → XP_038963403.1  dynein axonemal intermediate chain 7 isoform X7

    Conserved Domains (1) summary
    pfam15927
    Location:37 → 266
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  8. XM_039107472.2 → XP_038963400.1  dynein axonemal intermediate chain 7 isoform X6

    UniProtKB/TrEMBL
    A0A8I6ACC4
    Conserved Domains (1) summary
    pfam15927
    Location:1 → 136
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  9. XM_039107469.2 → XP_038963397.1  dynein axonemal intermediate chain 7 isoform X4

    UniProtKB/TrEMBL
    A0A8I6ACC4
    Conserved Domains (1) summary
    pfam15927
    Location:22 → 168
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  10. XM_039107468.2 → XP_038963396.1  dynein axonemal intermediate chain 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ACC4
    Conserved Domains (1) summary
    pfam15927
    Location:52 → 181
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  11. XM_039107477.2 → XP_038963405.1  dynein axonemal intermediate chain 7 isoform X9

    Conserved Domains (1) summary
    pfam15927
    Location:37 → 266
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  12. XM_039107479.2 → XP_038963407.1  dynein axonemal intermediate chain 7 isoform X11

    Conserved Domains (1) summary
    pfam15927
    Location:37 → 266
    Casc1_N; Cancer susceptibility candidate 1 N-terminus

  13. XM_039107478.2 → XP_038963406.1  dynein axonemal intermediate chain 7 isoform X10

    Conserved Domains (1) summary
    pfam15927
    Location:37 → 266
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
Nucleotide Protein Strain
Heading Accession and Version

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