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Mybl1 MYB proto-oncogene like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297783, updated on 2-Nov-2024

Summary

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Official Symbol
Mybl1provided by RGD
Official Full Name
MYB proto-oncogene like 1provided by RGD
Primary source
RGD:1306940
See related
EnsemblRapid:ENSRNOG00000021669 AllianceGenome:RGD:1306940
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including male meiosis I; positive regulation of DNA-templated transcription; and spermatogenesis. Predicted to act upstream of with a positive effect on siRNA-mediated retrotransposon silencing by heterochromatin formation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human MYBL1 (MYB proto-oncogene like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 58.5), Kidney (RPKM 34.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mybl1 in Genome Data Viewer
Location:
5q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (14365768..14401012)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9582905..9618179)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (9279756..9315112)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene interferon-induced transmembrane protein 2-like Neighboring gene valosin containing protein interacting protein 1 Neighboring gene vexin Neighboring gene alcohol dehydrogenase, iron containing, 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A-MYB (MYBL1) transcription factor is a master regulator of male meiosis. Bolcun-Filas E, et al. Development, 2011 Aug. PMID 21750041, Free PMC Article
  2. An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Li XZ, et al. Mol Cell, 2013 Apr 11. PMID 23523368, Free PMC Article
  3. DNA binding and transactivation activity of A-myb, a c-myb-related gene. Ma XP, et al. Cancer Res, 1994 Dec 15. PMID 7987850
  4. The transcription factor SOX30 is a key regulator of mouse spermiogenesis. Zhang D, et al. Development, 2018 May 30. PMID 29848638
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in male meiosis I ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of piRNA transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect siRNA-mediated retrotransposon silencing by heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myb-related protein A
Names
myeloblastosis oncogene-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106632.1 → NP_001100102.1  myb-related protein A

    See identical proteins and their annotated locations for NP_001100102.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473984
    UniProtKB/TrEMBL
    A0A8I6AI21, A6JFG1
    Related
    ENSRNOP00000099403.1, ENSRNOT00000132216.1
    Conserved Domains (4) summary
    smart00717
    Location:87 → 135
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:87 → 133
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:240 → 283
    LMSTEN; LMSTEN motif
    pfam09316
    Location:483 → 644
    Cmyb_C; C-myb, C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    14365768..14401012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237749.5 → XP_006237811.1  myb-related protein A isoform X2

    UniProtKB/TrEMBL
    A0A8I6AI21, A0A8I6ARW4
    Related
    ENSRNOP00000094567.1, ENSRNOT00000099850.2
    Conserved Domains (4) summary
    smart00717
    Location:87 → 135
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:87 → 133
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:242 → 285
    LMSTEN; LMSTEN motif
    pfam09316
    Location:485 → 646
    Cmyb_C; C-myb, C-terminal

  2. XM_006237752.5 → XP_006237814.1  myb-related protein A isoform X4

    UniProtKB/TrEMBL
    A0A8I6AI21, D3ZF01
    Related
    ENSRNOP00000062710.3, ENSRNOT00000067977.4
    Conserved Domains (4) summary
    smart00717
    Location:87 → 135
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:87 → 133
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:242 → 285
    LMSTEN; LMSTEN motif
    pfam09316
    Location:485 → 646
    Cmyb_C; C-myb, C-terminal

  3. XM_039109395.2 → XP_038965323.1  myb-related protein A isoform X3

    UniProtKB/TrEMBL
    A0A8I6AI21
    Conserved Domains (4) summary
    PLN03091
    Location:107 → 215
    PLN03091; hypothetical protein; Provisional
    pfam13921
    Location:61 → 121
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    pfam07988
    Location:265 → 308
    LMSTEN; LMSTEN motif
    pfam09316
    Location:508 → 667
    Cmyb_C; C-myb, C-terminal

  4. XM_039109393.2 → XP_038965321.1  myb-related protein A isoform X1

    UniProtKB/TrEMBL
    A0A8I6AI21
    Related
    ENSRNOP00000092705.2, ENSRNOT00000099708.2
    Conserved Domains (4) summary
    PLN03091
    Location:107 → 215
    PLN03091; hypothetical protein; Provisional
    pfam13921
    Location:61 → 121
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    pfam07988
    Location:265 → 308
    LMSTEN; LMSTEN motif
    pfam09316
    Location:508 → 667
    Cmyb_C; C-myb, C-terminal
Nucleotide Protein Strain
Heading Accession and Version

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