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Atp6v1h ATPase H+ transporting V1 subunit H [ Rattus norvegicus (Norway rat) ]

Gene ID: 297797, updated on 26-Jun-2024

Summary

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Official Symbol
Atp6v1hprovided by RGD
Official Full Name
ATPase H+ transporting V1 subunit Hprovided by RGD
Primary source
RGD:1562450
See related
Ensembl:ENSRNOG00000030862 AllianceGenome:RGD:1562450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SFD; VMA13; CGI-11; SFDbeta; SFDalpha
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in endocytosis. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Orthologous to human ATP6V1H (ATPase H+ transporting V1 subunit H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 419.0), Kidney (RPKM 330.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atp6v1h in Genome Data Viewer
Location:
5q12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (19176849..19282516, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (14379029..14484703, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (14262352..14367898, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene NHP2 ribonucleoprotein, pseudogene 2 Neighboring gene uncharacterized LOC108350923 Neighboring gene heat shock protein family D (Hsp60) member 1, pseudogene 36 Neighboring gene regulator of G-protein signaling 20 Neighboring gene transcription elongation factor A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery. Geyer M, et al. J Biol Chem, 2002 Aug 9. PMID 12032142
  2. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, et al. Neuron, 2013 Apr 24. PMID 23622064
  3. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
  4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle lumen acidification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extrinsic component of synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in extrinsic component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting V-type ATPase complex ISO
Inferred from Sequence Orthology
more info
  
part_of vacuolar proton-transporting V-type ATPase, V1 domain IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
V-type proton ATPase subunit H
Names
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
ATPase, H+ transporting, lysosomal V1 subunit H
V-ATPase H subunit
vacuolar ATP synthase subunit H
vacuolar ATPase subunit H
vacuolar proton pump H subunit
NP_001013951.1
NP_001385914.1
NP_001385915.1
XP_006237864.1
XP_006237866.1
XP_008761746.1
XP_063143342.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013929.1 → NP_001013951.1  V-type proton ATPase subunit H isoform 2

    See identical proteins and their annotated locations for NP_001013951.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083669
    UniProtKB/TrEMBL
    E9PTI1, Q5XIL1
    Related
    ENSRNOP00000059400.1, ENSRNOT00000065402.2
    Conserved Domains (1) summary
    cd00256
    Location:17 → 423
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...

  2. NM_001398985.1 → NP_001385914.1  V-type proton ATPase subunit H isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I5ZQ24, A0A8I5ZWI2, A6JFI5
    Related
    ENSRNOP00000080326.1, ENSRNOT00000107603.1
    Conserved Domains (1) summary
    cd00256
    Location:17 → 465
    VATPase_H; regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The topology is ...

  3. NM_001398986.1 → NP_001385915.1  V-type proton ATPase subunit H isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I5ZWI2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    19176849..19282516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237802.4 → XP_006237864.1  V-type proton ATPase subunit H isoform X1

    See identical proteins and their annotated locations for XP_006237864.1

    UniProtKB/TrEMBL
    A0A8I5ZQ24, A0A8I5ZWI2, A6JFI5
    Related
    ENSRNOP00000083793.1
    Conserved Domains (1) summary
    cd00256
    Location:17 → 465
    VATPase_H; regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The topology is ...

  2. XM_063287272.1 → XP_063143342.1  V-type proton ATPase subunit H isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZWI2, A0A8I6ACJ2

  3. XM_006237804.4 → XP_006237866.1  V-type proton ATPase subunit H isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZWI2, A0A8I6ACJ2
    Related
    ENSRNOP00000089383.1
    Conserved Domains (1) summary
    cd00256
    Location:17 → 447
    VATPase_H; regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The topology is ...

  4. XM_008763524.3 → XP_008761746.1  V-type proton ATPase subunit H isoform X3

    UniProtKB/TrEMBL
    A0A8I6AIG1
    Related
    ENSRNOP00000093916.1
    Conserved Domains (1) summary
    cd00256
    Location:1 → 425
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
Nucleotide Protein Strain
Heading Accession and Version

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