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Mrpl15 mitochondrial ribosomal protein L15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297799, updated on 2-Nov-2024

Summary

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Official Symbol
Mrpl15provided by RGD
Official Full Name
mitochondrial ribosomal protein L15provided by RGD
Primary source
RGD:1304796
See related
EnsemblRapid:ENSRNOG00000008566 AllianceGenome:RGD:1304796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL15 (mitochondrial ribosomal protein L15). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 333.9), Heart (RPKM 309.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrpl15 in Genome Data Viewer
Location:
5q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (19527745..19539061)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (14729961..14741276)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (14609656..14620965)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A1 Neighboring gene lysophospholipase 1 Neighboring gene uncharacterized LOC102552817 Neighboring gene uncharacterized LOC120102814 Neighboring gene SRY-box transcription factor 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
  2. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  3. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
  4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL15m
Names
39S ribosomal protein L15, mitochondrial
NP_001100103.1
NP_001385932.1
NP_001385936.1
NP_001385937.1
NP_001385938.1
XP_063143343.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106633.2 → NP_001100103.1  large ribosomal subunit protein uL15m isoform 2

    See identical proteins and their annotated locations for NP_001100103.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6JFJ4, D4A4A7, D4A4B1
    Conserved Domains (1) summary
    pfam00828
    Location:52 → 175
    Ribosomal_L18e; Ribosomal protein L18e/L15

  2. NM_001399003.1 → NP_001385932.1  large ribosomal subunit protein uL15m isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6A254, A6JFJ5
    Related
    ENSRNOP00000085368.1, ENSRNOT00000117082.2
    Conserved Domains (1) summary
    pfam00828
    Location:52 → 175
    Ribosomal_L27A; Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A

  3. NM_001399007.1 → NP_001385936.1  large ribosomal subunit protein uL15m isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  4. NM_001399008.1 → NP_001385937.1  large ribosomal subunit protein uL15m isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    Related
    ENSRNOP00000074933.3, ENSRNOT00000085621.3

  5. NM_001399009.1 → NP_001385938.1  large ribosomal subunit protein uL15m isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K9B4
    Conserved Domains (1) summary
    pfam00828
    Location:52 → 140
    Ribosomal_L27A; Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A

RNA

  1. NR_174148.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    19527745..19539061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287273.1 → XP_063143343.1  large ribosomal subunit protein uL15m isoform X1

    UniProtKB/TrEMBL
    A6JFJ6
    Related
    ENSRNOP00000077151.1, ENSRNOT00000115029.2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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