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OLA1 Obg like ATPase 1 [ Homo sapiens (human) ]

Gene ID: 29789, updated on 3-Nov-2024

Summary

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Official Symbol
OLA1provided by HGNC
Official Full Name
Obg like ATPase 1provided by HGNC
Primary source
HGNC:HGNC:28833
See related
Ensembl:ENSG00000138430 MIM:611175; AllianceGenome:HGNC:28833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOC45; GBP45; GTBP9; GTPBP9; PTD004
Summary
This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]
Expression
Ubiquitous expression in brain (RPKM 15.5), thyroid (RPKM 14.3) and 25 other tissues See more
Orthologs
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Genomic context

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See OLA1 in Genome Data Viewer
Location:
2q31.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (174072447..174248532, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (174558800..174736966, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (174937175..175113260, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr2:174914257-174914460 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:174916218-174917417 Neighboring gene uncharacterized LOC105373746 Neighboring gene ribosomal protein SA pseudogene 24 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:174927623-174928242 Neighboring gene NANOG hESC enhancer GRCh37_chr2:174948503-174949105 Neighboring gene VISTA enhancer hs243 Neighboring gene VISTA enhancer hs244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12123 Neighboring gene uncharacterized LOC124907906 Neighboring gene MPRA-validated peak3933 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12124 Neighboring gene RNA, 7SL, cytoplasmic 65, pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 39 Neighboring gene LRRC2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. OLA1 gene sequencing in patients with BRCA1/2 mutation-negative suspected hereditary breast and ovarian cancer. Takahashi M, et al. Breast Cancer, 2017 Mar. PMID 27271530
  2. Knockdown of OLA1, a regulator of oxidative stress response, inhibits motility and invasion of breast cancer cells. Zhang JW, et al. J Zhejiang Univ Sci B, 2009 Nov. PMID 19882753, Free PMC Article
  3. The identification and characterization of a new GTP-binding protein (Gbp45) involved in cell proliferation and death related to mitochondrial function. Kira Y, et al. Cell Mol Biol Lett, 2008. PMID 18536999, Free PMC Article
  4. Regulation of cell-matrix adhesion by OLA1, the Obg-like ATPase 1. Jeyabal PV, et al. Biochem Biophys Res Commun, 2014 Feb 21. PMID 24486488, Free PMC Article
  5. OLA1 in centrosome biology alongside the BRCA1/BARD1 complex: looking beyond centrosomes. Gomez V, et al. Mol Cell, 2014 Jan 9. PMID 24411079, Free PMC Article

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinicopathological significance of Obg-like ATPase 1 and its association with Snail in gastric cancer.
    Title: Clinicopathological significance of  Obg-like ATPase 1 and its association with Snail in gastric cancer.
  2. OLA1 Phosphorylation Governs the Mitochondrial Bioenergetic Function of Pulmonary Vascular Cells.
    Title: OLA1 Phosphorylation Governs the Mitochondrial Bioenergetic Function of Pulmonary Vascular Cells.
  3. OLA1 promotes colorectal cancer tumorigenesis by activation of HIF1alpha/CA9 axis.
    Title: OLA1 promotes colorectal cancer tumorigenesis by activation of HIF1α/CA9 axis.
  4. N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: implication in colorectal cancer.
    Title: N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: implication in colorectal cancer.
  5. HIV p17 enhances T cell proliferation by suppressing autophagy through the p17-OLA1-GSK3beta axis under nutrient starvation.
    Title: HIV p17 enhances T cell proliferation by suppressing autophagy through the p17-OLA1-GSK3β axis under nutrient starvation.
  6. Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGFbeta/SMAD2 axis in vitro.
    Title: Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGFβ/SMAD2 axis in vitro.
  7. Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma.
    Title: Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma.
  8. It explores the various functional roles of hOLA1 in mammalian cells during stress response and cancer progression, and of YchF in bacterial cells.
    Title: Cellular roles of the human Obg-like ATPase 1 (hOLA1) and its YchF homologs.
  9. We conclude that decreased OLA1 expression accounts for SOD2 downregulation in persistent pulmonary hypertension of the newborn.
    Title: Decreased OLA1 (Obg-Like ATPase-1) Expression Drives Ubiquitin-Proteasome Pathways to Downregulate Mitochondrial SOD2 (Superoxide Dismutase) in Persistent Pulmonary Hypertension of the Newborn.
  10. these data reveal that the OLA1-BARD1 interaction is important for the regulation of centrosome number. Regulation of centrosome number by BRCA1/BARD1 together with OLA1 is important for the genome integrity to prevent tumor development.
    Title: BRCA1-Interacting Protein OLA1 Requires Interaction with BARD1 to Regulate Centrosome Number.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with Obg-like ATPase 1 (OLA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
matrix gag HIV-1 MA interacts with OLA1 PubMed
gag HIV-1 MA is identified to have a physical interaction with Obg-like ATPase 1 (OLA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp313H1942

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables cadherin binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosomal large subunit binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
obg-like ATPase 1
Names
DNA damage-regulated overexpressed in cancer 45 protein
GTP-binding protein 9 (putative)
GTP-binding protein PTD004
homologous yeast-44.2 protein
NP_001011708.1
NP_001315617.1
NP_037473.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051001.1 RefSeqGene

    Range
    5139..181224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001011708.3 → NP_001011708.1  obg-like ATPase 1 isoform 2

    See identical proteins and their annotated locations for NP_001011708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC016737, AK074710
    Consensus CDS
    CCDS42779.1
    UniProtKB/TrEMBL
    Q53SQ6
    Related
    ENSP00000340167.5, ENST00000344357.9
    Conserved Domains (1) summary
    PTZ00258
    Location:1 → 232
    PTZ00258; GTP-binding protein; Provisional

  2. NM_001328688.2 → NP_001315617.1  obg-like ATPase 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC016737, AK225112
    UniProtKB/TrEMBL
    J3KQ32
    Conserved Domains (1) summary
    PTZ00258
    Location:1 → 369
    PTZ00258; GTP-binding protein; Provisional

  3. NM_013341.5 → NP_037473.3  obg-like ATPase 1 isoform 1

    See identical proteins and their annotated locations for NP_037473.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC016737, BC012842
    Consensus CDS
    CCDS2255.1
    UniProtKB/Swiss-Prot
    D7EHM2, Q5BJD7, Q8NCI8, Q96CU1, Q96SV2, Q9NTK5, Q9P1D3, Q9UNY9, Q9Y6G4
    UniProtKB/TrEMBL
    J3KQ32
    Related
    ENSP00000284719.3, ENST00000284719.8
    Conserved Domains (1) summary
    PTZ00258
    Location:1 → 390
    PTZ00258; GTP-binding protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    174072447..174248532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    174558800..174736966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NTK5.2 GenPept UniProtKB/Swiss-Prot:Q9NTK5

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