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Ube2j1 ubiquitin-conjugating enzyme E2, J1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297961, updated on 2-Nov-2024

Summary

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Official Symbol
Ube2j1provided by RGD
Official Full Name
ubiquitin-conjugating enzyme E2, J1provided by RGD
Primary source
RGD:1305067
See related
EnsemblRapid:ENSRNOG00000007434 AllianceGenome:RGD:1305067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including ERAD pathway; negative regulation of retrograde protein transport, ER to cytosol; and protein N-linked glycosylation via asparagine. Predicted to act upstream of or within regulation of macrophage cytokine production; regulation of tumor necrosis factor production; and spermatid development. Predicted to be active in endoplasmic reticulum membrane and nucleus. Orthologous to human UBE2J1 (ubiquitin conjugating enzyme E2 J1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 242.0), Spleen (RPKM 213.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ube2j1 in Genome Data Viewer
Location:
5q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (52218807..52237805)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (47422476..47441476)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (48274387..48292699)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene Ras-related GTP binding D Neighboring gene uncharacterized LOC108350947 Neighboring gene ribonuclease P/MRP subunit p38, pseudogene 1 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho 2 Neighboring gene uncharacterized LOC120102852

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The E2 ubiquitin-conjugating enzyme UBE2J1 is required for spermiogenesis in mice. Koenig PA, et al. J Biol Chem, 2014 Dec 12. PMID 25320092, Free PMC Article
  2. Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production. Menon MB, et al. Biochem J, 2013 Dec 1. PMID 24020373
  3. HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation. Burr ML, et al. Proc Natl Acad Sci U S A, 2011 Feb 1. PMID 21245296, Free PMC Article
  4. An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Imai Y, et al. Cell, 2001 Jun 29. PMID 11439185
  5. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. Sato T, et al. Mol Cell, 2012 Jul 13. PMID 22607976

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of macrophage cytokine production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 J1
Names
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
NP_001100112.2
XP_008761834.1
XP_038965356.1
XP_038965357.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106642.2 → NP_001100112.2  ubiquitin-conjugating enzyme E2 J1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A096MKH4, A0A8I6A9S4
    Related
    ENSRNOP00000090289.2, ENSRNOT00000110935.2
    Conserved Domains (1) summary
    cd00195
    Location:12 → 119
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    52218807..52237805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109428.2 → XP_038965356.1  ubiquitin-conjugating enzyme E2 J1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9S4
    Related
    ENSRNOP00000068517.3, ENSRNOT00000075992.4
    Conserved Domains (1) summary
    cd00195
    Location:1 → 104
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. XM_039109429.2 → XP_038965357.1  ubiquitin-conjugating enzyme E2 J1 isoform X2

    UniProtKB/TrEMBL
    A6IIK6
    Related
    ENSRNOP00000112829.1, ENSRNOT00000156136.1
    Conserved Domains (1) summary
    cd00195
    Location:12 → 119
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. XM_008763612.3 → XP_008761834.1  ubiquitin-conjugating enzyme E2 J1 isoform X3

    See identical proteins and their annotated locations for XP_008761834.1

    UniProtKB/TrEMBL
    A0A8I6A9S4, A6IIK5
    Conserved Domains (1) summary
    cd00195
    Location:12 → 119
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein Strain
Heading Accession and Version

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