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REPIN1 replication initiator 1 [ Homo sapiens (human) ]

Gene ID: 29803, updated on 5-Mar-2024

Summary

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Official Symbol
REPIN1provided by HGNC
Official Full Name
replication initiator 1provided by HGNC
Primary source
HGNC:HGNC:17922
See related
Ensembl:ENSG00000214022 MIM:619039; AllianceGenome:HGNC:17922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP4; RIP60; ZNF464; Zfp464
Summary
Enables RNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of glucose import and regulation of fatty acid transport. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 20.6), spleen (RPKM 16.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See REPIN1 in Genome Data Viewer
Location:
7q36.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150368096..150374039)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151546435..151552378)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150065185..150071128)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18774 Neighboring gene uncharacterized LOC107986858 Neighboring gene retinoic acid receptor responder 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:150044724-150044956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18775 Neighboring gene REPIN1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26823 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150065484-150066288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150066289-150067094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150067095-150067899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150078931-150079888 Neighboring gene ZNF775 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150080845-150081800 Neighboring gene zinc finger protein 775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150083270-150083842 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150083843-150084413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150085648-150086246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150096281-150096868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150096869-150097456 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150097787-150098311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150098312-150098835 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:150098842-150099517 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150099518-150100192 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150100193-150100867 Neighboring gene zinc finger domain-containing protein LOC728743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150103235-150103743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26828

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Human REPIN1 Gene Variant: Genetic Risk Factor for the Development of Nonalcoholic Fatty Liver Disease. Abshagen K, et al. Clin Transl Gastroenterol, 2020 Jan. PMID 31922994, Free PMC Article
  2. Metabolic effects of genetic variation in the human REPIN1 gene. Krüger J, et al. Int J Obes (Lond), 2019 Apr. PMID 29915365
  3. Crosstalk of AP4 and TGFβ receptor signaling in NSCLC. Wang W, et al. Tumour Biol, 2015 Jan. PMID 25266805
  4. Condensation by DNA looping facilitates transfer of large DNA molecules into mammalian cells. Montigny WJ, et al. Nucleic Acids Res, 2001 May 1. PMID 11328883, Free PMC Article
  5. The dhfr oribeta-binding protein RIP60 contains 15 zinc fingers: DNA binding and looping by the central three fingers and an associated proline-rich region. Houchens CR, et al. Nucleic Acids Res, 2000 Jan 15. PMID 10606657, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis.
    Title: REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis.
  2. Overexpression of miR-127 Predicts Poor Prognosis and Contributes to the Progression of Papillary Thyroid Cancer by Targeting REPIN1.
    Title: Overexpression of miR-127 Predicts Poor Prognosis and Contributes to the Progression of Papillary Thyroid Cancer by Targeting REPIN1.
  3. A Human REPIN1 Gene Variant: Genetic Risk Factor for the Development of Nonalcoholic Fatty Liver Disease.
    Title: A Human REPIN1 Gene Variant: Genetic Risk Factor for the Development of Nonalcoholic Fatty Liver Disease.
  4. data suggest that genetic variation in human REPIN1 plays a role in glucose and lipid metabolism by differentially affecting the expression of REPIN1 target genes including glucose and fatty acid transporters
    Title: Metabolic effects of genetic variation in the human REPIN1 gene.
  5. Increased expression of hsa-mir-127 and decreased expression of REPIN1 were both associated with poor overall survival
    Title: Hsa-mir-127 impairs survival of patients with glioma and promotes proliferation, migration and invasion of cancerous cells by modulating replication initiator 1.
  6. AP4 and LAPTM4B are highly coexpressed in hepatocellular carcinoma tissues, and their coexpression may be a marker of poor prognosis.
    Title: AP4 positively regulates LAPTM4B to promote hepatocellular carcinoma growth and metastasis, while reducing chemotherapy sensitivity.
  7. Results show that breast cancer cells underwent epithelial-mesenchymal transition when AP4 was upregulated, and that AP4 regulated p53 expression level suggesting AP4 can regulate cell migration via the activity of p53.
    Title: AP4 activates cell migration and EMT mediated by p53 in MDA-MB-231 breast carcinoma cells.
  8. AP4 is transcriptionally activated by TGFB1 to inhibit phosphorylation of SMAD2 as a negative regulator of an activated TGFB receptor signaling on cell growth inhibition in non-small cell lung cancer
    Title: Crosstalk of AP4 and TGFβ receptor signaling in NSCLC.
  9. there is a p53-induced double-negative feedback loop involving miR-15a/16-1 and AP4 that stabilizes epithelial and mesenchymal states, respectively, which may determine metastatic prowess in colorectal cancer
    Title: p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer.
  10. a potential role for Repin1 as regulator of adipocyte size was shown.Repin1 seems to be involved in the regulation of genes involved in adipogenesis.
    Title: Repin1 maybe involved in the regulation of cell size and glucose transport in adipocytes.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of replication initiator 1 (REPIN1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables RNA binding HDA PubMed 
enables chromatin insulator sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear origin of replication recognition complex TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
replication initiator 1
Names
60 kDa origin-specific DNA-binding protein
60 kDa replication initiation region protein
ATT-binding protein
DHFR oribeta-binding protein RIP60
H_DJ0584D14.12
replication initiation region protein (60kD)
zinc finger protein 464 (RIP60)
zinc finger protein AP4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099695.2 → NP_001093165.1  replication initiator 1 isoform 3

    See identical proteins and their annotated locations for NP_001093165.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate segment, compared to variant 1, that results in the use of an upstream start codon. The predicted protein (isoform 3) has a distinct N-terminus compared to isoform 1. Variants 4 and 7-10 all encode the same isoform (3).
    Source sequence(s)
    AL046625, BC000363, CN386958
    Consensus CDS
    CCDS47745.1
    UniProtKB/Swiss-Prot
    Q9BWE0
    Related
    ENSP00000417291.2, ENST00000489432.7
    Conserved Domains (2) summary
    COG5048
    Location:290 → 597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001099696.3 → NP_001093166.1  replication initiator 1 isoform 1

    See identical proteins and their annotated locations for NP_001093166.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, 5, 6, and 17-36 all encode the same isoform (1).
    Source sequence(s)
    AC005586, BC000363
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Related
    ENSP00000407714.1, ENST00000444957.3
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001362745.2 → NP_001349674.1  replication initiator 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005586, BC000363, CN386958
    Consensus CDS
    CCDS47745.1
    Conserved Domains (2) summary
    COG5048
    Location:290 → 597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001362746.2 → NP_001349675.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586, AK292670, BC000363, BX443182, DB158657
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001362747.2 → NP_001349676.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    BC000363, CD675150, CX166683
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001388037.1 → NP_001374966.1  replication initiator 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) encodes the longest isoform (4).
    Source sequence(s)
    AC005586
    Conserved Domains (2) summary
    COG5048
    Location:292 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:520 → 540
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001388038.1 → NP_001374967.1  replication initiator 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS47745.1
    Conserved Domains (2) summary
    COG5048
    Location:290 → 597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. NM_001388039.1 → NP_001374968.1  replication initiator 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS47745.1
    Conserved Domains (2) summary
    COG5048
    Location:290 → 597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. NM_001388040.1 → NP_001374969.1  replication initiator 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS47745.1
    Conserved Domains (2) summary
    COG5048
    Location:290 → 597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. NM_001388041.1 → NP_001374970.1  replication initiator 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Conserved Domains (2) summary
    COG5048
    Location:289 → 596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:517 → 537
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. NM_001388042.1 → NP_001374971.1  replication initiator 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Conserved Domains (2) summary
    COG5048
    Location:289 → 596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:517 → 537
    ZF_C2H2; C2H2 Zn finger [structural motif]

  12. NM_001388043.1 → NP_001374972.1  replication initiator 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Conserved Domains (2) summary
    COG5048
    Location:289 → 596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:517 → 537
    ZF_C2H2; C2H2 Zn finger [structural motif]

  13. NM_001388044.1 → NP_001374973.1  replication initiator 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Conserved Domains (2) summary
    COG5048
    Location:289 → 596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:517 → 537
    ZF_C2H2; C2H2 Zn finger [structural motif]

  14. NM_001388045.1 → NP_001374974.1  replication initiator 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Conserved Domains (2) summary
    COG5048
    Location:289 → 596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:517 → 537
    ZF_C2H2; C2H2 Zn finger [structural motif]

  15. NM_001388046.1 → NP_001374975.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  16. NM_001388047.1 → NP_001374976.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  17. NM_001388048.1 → NP_001374977.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  18. NM_001388049.1 → NP_001374978.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  19. NM_001388050.1 → NP_001374979.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  20. NM_001388051.1 → NP_001374980.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  21. NM_001388052.1 → NP_001374981.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  22. NM_001388053.1 → NP_001374982.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  23. NM_001388054.1 → NP_001374983.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  24. NM_001388055.1 → NP_001374984.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  25. NM_001388056.1 → NP_001374985.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  26. NM_001388057.1 → NP_001374986.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  27. NM_001388058.1 → NP_001374987.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  28. NM_001388059.1 → NP_001374988.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  29. NM_001388060.1 → NP_001374989.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  30. NM_001388061.1 → NP_001374990.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  31. NM_001388062.1 → NP_001374991.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  32. NM_001388063.1 → NP_001374992.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  33. NM_001388064.1 → NP_001374993.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Related
    ENSP00000388287.2, ENST00000425389.2
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  34. NM_001388065.1 → NP_001374994.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  35. NM_013400.4 → NP_037532.2  replication initiator 1 isoform 1

    See identical proteins and their annotated locations for NP_037532.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 3, 5, 6, and 17-36 all encode the same isoform (1).
    Source sequence(s)
    AL046625, BC000363, CX166683
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Related
    ENSP00000380451.2, ENST00000397281.6
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    150368096..150374039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446737.2 → XP_024302505.1  replication initiator 1 isoform X1

    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_024446738.2 → XP_024302506.1  replication initiator 1 isoform X1

    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461 → 481
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_047420279.1 → XP_047276235.1  replication initiator 1 isoform X1

    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1

  4. XM_047420278.1 → XP_047276234.1  replication initiator 1 isoform X1

    UniProtKB/Swiss-Prot
    C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
    UniProtKB/TrEMBL
    A0A090N8H1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    151546435..151552378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358014.1 → XP_054213989.1  replication initiator 1 isoform X1

  2. XM_054358015.1 → XP_054213990.1  replication initiator 1 isoform X1

  3. XM_054358017.1 → XP_054213992.1  replication initiator 1 isoform X1

  4. XM_054358016.1 → XP_054213991.1  replication initiator 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014374.3: Suppressed sequence

    Description
    NM_014374.3: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BWE0.1 GenPept UniProtKB/Swiss-Prot:Q9BWE0

Gene LinkOut

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