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Rabgap1l RAB GTPase activating protein 1-like [ Mus musculus (house mouse) ]

Gene ID: 29809, updated on 2-Nov-2024

Summary

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Official Symbol
Rabgap1lprovided by MGI
Official Full Name
RAB GTPase activating protein 1-likeprovided by MGI
Primary source
MGI:MGI:1352507
See related
Ensembl:ENSMUSG00000026721 AllianceGenome:MGI:1352507
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HHL; Hh1; mKIAA0471; 5830411O09Rik; 8430421H08Rik; 9630005B12Rik
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in regulation of protein localization. Predicted to be located in Golgi apparatus; early endosome; and nucleus. Is expressed in several structures, including heart; immune system; nervous system; retina nuclear layer; and yolk sac. Orthologous to human RABGAP1L (RAB GTPase activating protein 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 3.6), CNS E18 (RPKM 3.4) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Rabgap1l in Genome Data Viewer
Location:
1 H2.1; 1 69.64 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (160046744..160621046, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (160219174..160793476, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02795 Neighboring gene RIKEN cDNA 4933417C20 gene Neighboring gene STARR-seq mESC enhancer starr_02796 Neighboring gene STARR-seq mESC enhancer starr_02797 Neighboring gene STARR-seq mESC enhancer starr_02798 Neighboring gene STARR-positive B cell enhancer ABC_E9188 Neighboring gene STARR-positive B cell enhancer ABC_E5830 Neighboring gene STARR-positive B cell enhancer ABC_E5831 Neighboring gene calcyclin binding protein Neighboring gene STARR-seq mESC enhancer starr_02799 Neighboring gene STARR-seq mESC enhancer starr_02800 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:162237326-162237707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:162239161-162239370 Neighboring gene microRNA 1927 Neighboring gene STARR-seq mESC enhancer starr_02802 Neighboring gene STARR-seq mESC enhancer starr_02803 Neighboring gene STARR-positive B cell enhancer ABC_E5832 Neighboring gene STARR-seq mESC enhancer starr_02805 Neighboring gene STARR-seq mESC enhancer starr_02807 Neighboring gene G protein-coupled receptor 52 Neighboring gene predicted gene, 23528 Neighboring gene STARR-seq mESC enhancer starr_02810 Neighboring gene STARR-positive B cell enhancer mm9_chr1:162722911-162723212 Neighboring gene STARR-positive B cell enhancer ABC_E7764 Neighboring gene predicted gene, 37083 Neighboring gene STARR-positive B cell enhancer ABC_E5833 Neighboring gene STARR-positive B cell enhancer ABC_E8983 Neighboring gene predicted gene, 24988 Neighboring gene ribosomal protein L23A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes. Qu F, et al. Elife, 2016 Oct 8. PMID 27718357, Free PMC Article
  2. Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells. Hidaka M, et al. Mech Dev, 2000 Jan. PMID 10585558
  3. Large-scale phosphorylation analysis of mouse liver. Villén J, et al. Proc Natl Acad Sci U S A, 2007 Jan 30. PMID 17242355, Free PMC Article
  4. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Itoh T, et al. Genes Cells, 2006 Sep. PMID 16923123
  5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in megakaryocyte development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
rab GTPase-activating protein 1-like
Names
rab6 GTPase activating protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038621.2 → NP_001033710.1  rab GTPase-activating protein 1-like isoform b

    See identical proteins and their annotated locations for NP_001033710.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK147634
    Consensus CDS
    CCDS15407.1
    UniProtKB/Swiss-Prot
    A6H6A9
    Related
    ENSMUSP00000028052.6, ENSMUST00000028052.12
    Conserved Domains (1) summary
    TIGR02168
    Location:113 → 322
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_013862.5 → NP_038890.3  rab GTPase-activating protein 1-like isoform a

    See identical proteins and their annotated locations for NP_038890.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC154873, AK035796, BC145811
    Consensus CDS
    CCDS15408.1
    UniProtKB/Swiss-Prot
    A6H6A9, Q3UH20, Q80TZ4, Q8BZD2, Q8BZP0, Q8CFI6, Q9QY69
    Related
    ENSMUSP00000028049.8, ENSMUST00000028049.13
    Conserved Domains (3) summary
    cd01211
    Location:129 → 257
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam00566
    Location:541 → 744
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12473
    Location:340 → 421
    DUF3694; Kinesin protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    160046744..160621046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496875.1 → XP_006496938.1  rab GTPase-activating protein 1-like isoform X1

    Conserved Domains (4) summary
    COG1196
    Location:814 → 1019
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01211
    Location:129 → 257
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam00566
    Location:541 → 744
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12473
    Location:290 → 421
    DUF3694; Kinesin protein

  2. XM_006496878.4 → XP_006496941.1  rab GTPase-activating protein 1-like isoform X4

    Conserved Domains (4) summary
    COG1196
    Location:756 → 961
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01211
    Location:71 → 199
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam00566
    Location:483 → 686
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12473
    Location:232 → 363
    DUF3694; Kinesin protein

  3. XM_006496876.2 → XP_006496939.1  rab GTPase-activating protein 1-like isoform X2

    Conserved Domains (4) summary
    COG1196
    Location:786 → 991
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01211
    Location:101 → 229
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam00566
    Location:513 → 716
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12473
    Location:262 → 393
    DUF3694; Kinesin protein

  4. XM_006496877.3 → XP_006496940.1  rab GTPase-activating protein 1-like isoform X3

    Conserved Domains (4) summary
    COG1196
    Location:777 → 982
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01211
    Location:92 → 220
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam00566
    Location:504 → 707
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12473
    Location:253 → 384
    DUF3694; Kinesin protein

  5. XM_006496881.5 → XP_006496944.1  rab GTPase-activating protein 1-like isoform X6

    Conserved Domains (1) summary
    COG1196
    Location:68 → 276
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. XM_030254804.2 → XP_030110664.1  rab GTPase-activating protein 1-like isoform X7

    Conserved Domains (1) summary
    COG1196
    Location:62 → 276
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_030254802.2 → XP_030110662.1  rab GTPase-activating protein 1-like isoform X6

    Conserved Domains (1) summary
    COG1196
    Location:68 → 276
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  8. XM_036165642.1 → XP_036021535.1  rab GTPase-activating protein 1-like isoform X5

    Conserved Domains (3) summary
    cd01211
    Location:101 → 229
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam00566
    Location:513 → 716
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12473
    Location:262 → 393
    DUF3694; Kinesin protein

  9. XM_030254805.1 → XP_030110665.1  rab GTPase-activating protein 1-like isoform X8

  10. XM_006496883.5 → XP_006496946.1  rab GTPase-activating protein 1-like isoform X9

    See identical proteins and their annotated locations for XP_006496946.1

    UniProtKB/Swiss-Prot
    A6H6A9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6H6A9.1 GenPept UniProtKB/Swiss-Prot:A6H6A9

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