Pole3 DNA polymerase epsilon 3, accessory subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pole3provided by RGD
Official Full Name: DNA polymerase epsilon 3, accessory subunitprovided by RGD
Primary source: RGD:1359475
See related: EnsemblRapid:ENSRNOG00000070688 AllianceGenome:RGD:1359475
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chromatin DNA binding activity. Predicted to be involved in several processes, including chromatin remodeling; leading strand elongation; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in pericentric heterochromatin. Predicted to be part of ATAC complex; CHRAC; and epsilon DNA polymerase complex. Orthologous to human POLE3 (DNA polymerase epsilon 3, accessory subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 144.3), Thymus (RPKM 119.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (80989508..80992742, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (75973941..75977175, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (78380813..78384047, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in leading strand elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
part_of CHRAC	IBA Inferred from Biological aspect of Ancestor more info
part_of epsilon DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of epsilon DNA polymerase complex	ISO Inferred from Sequence Orthology more info
part_of epsilon DNA polymerase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA polymerase epsilon subunit 3

Names: DNA polymerase II subunit 3; DNA polymerase epsilon subunit p17; DNA-directed DNA polymerase epsilon 3; polymerase (DNA directed), epsilon 3 (p17 subunit); polymerase (DNA directed), epsilon 3, accessory subunit; polymerase (DNA) epsilon 3, accessory subunit

NP_001007653.1

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007652.2 → NP_001007653.1 DNA polymerase epsilon subunit 3

See identical proteins and their annotated locations for NP_001007653.1

Status: PROVISIONAL

Source sequence(s)

BC083800

UniProtKB/Swiss-Prot

Q642A5

UniProtKB/TrEMBL

A6J7V8

Related

ENSRNOP00000093308.2, ENSRNOT00000112884.2

Conserved Domains (1) summary

cl23735
Location:1 → 105

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...