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Gpx7 glutathione peroxidase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298376, updated on 2-Nov-2024

Summary

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Official Symbol
Gpx7provided by RGD
Official Full Name
glutathione peroxidase 7provided by RGD
Primary source
RGD:1306999
See related
EnsemblRapid:ENSRNOG00000009751 AllianceGenome:RGD:1306999
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable catalase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Barrett's adenocarcinoma and Barrett's esophagus. Orthologous to human GPX7 (glutathione peroxidase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 170.1), Heart (RPKM 111.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpx7 in Genome Data Viewer
Location:
5q34
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (128373881..128381866, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (123145151..123153141, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (128001766..128009610, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase assembly factor 7 Neighboring gene shisa like 2A Neighboring gene terminal uridylyl transferase 4 Neighboring gene ribosomal protein L9, pseudogene 7 Neighboring gene 40S ribosomal protein S27-like Neighboring gene small nucleolar RNA SNORA40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity. Mehmeti I, et al. Free Radic Biol Med, 2017 Nov. PMID 28751022
  2. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Peng D, et al. Gut, 2012 Sep. PMID 22157330, Free PMC Article
  3. DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. Peng DF, et al. Gut, 2009 Jan. PMID 18664505, Free PMC Article
  4. Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation. Nguyen VD, et al. J Mol Biol, 2011 Feb 25. PMID 21215271
  5. Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns. Cueto-Ureña C, et al. Genes (Basel), 2023 Aug 24. PMID 37761814, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns.
    Title: Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns.
  2. Endoplasmic reticulum (ER)-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting beta-cells against lipotoxicity by improving the ER antioxidative capacity.
    Title: ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables catalase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutathione peroxidase 7
NP_001100143.1
XP_038965504.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106673.1 → NP_001100143.1  glutathione peroxidase 7 precursor

    See identical proteins and their annotated locations for NP_001100143.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474008
    UniProtKB/TrEMBL
    A0A8I6ARN0, A6JYU9, D3ZQI1
    Related
    ENSRNOP00000013913.5, ENSRNOT00000013913.8
    Conserved Domains (1) summary
    TIGR02540
    Location:23 → 175
    gpx7; putative glutathione peroxidase Gpx7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    128373881..128381866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109576.2 → XP_038965504.1  glutathione peroxidase 7 isoform X1

    Conserved Domains (1) summary
    cl00388
    Location:23 → 133
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein Strain
Heading Accession and Version

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