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Nsun4 NOP2/Sun RNA methyltransferase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298426, updated on 2-Nov-2024

Summary

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Symbol
Nsun4provided by RGD
Full Name
NOP2/Sun RNA methyltransferase 4provided by RGD
Primary source
RGD:1559652
See related
EnsemblRapid:ENSRNOG00000012020 AllianceGenome:RGD:1559652
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559652
Summary
Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity and small ribosomal subunit rRNA binding activity. Predicted to be involved in cytosolic ribosome assembly; positive regulation of mitochondrial translation; and rRNA methylation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human NSUN4 (NOP2/Sun RNA methyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 113.1), Muscle (RPKM 81.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nsun4 in Genome Data Viewer
Location:
5q35
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134749024..134773630, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129511224..129532498, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (134885377..134905492, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene diencephalon/mesencephalon homeobox 1 Neighboring gene fatty acid amide hydrolase Neighboring gene uncharacterized LOC134486970 Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene leucine rich repeat containing 41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure of the essential MTERF4:NSUN4 protein complex reveals how an MTERF protein collaborates to facilitate rRNA modification. Yakubovskaya E, et al. Structure, 2012 Nov 7. PMID 23022348, Free PMC Article
  2. NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly. Metodiev MD, et al. PLoS Genet, 2014 Feb. PMID 24516400, Free PMC Article
  3. MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cámara Y, et al. Cell Metab, 2011 May 4. PMID 21531335
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (cytosine-C5-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables rRNA methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables small ribosomal subunit rRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cytosolic ribosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
5-methylcytosine rRNA methyltransferase NSUN4
Names
NOL1/NOP2/Sun domain family, member 4
NOP2/Sun RNA methyltransferase family member 4
NOP2/Sun domain family, member 4
NP_001100148.1
XP_038965521.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106678.1 → NP_001100148.1  5-methylcytosine rRNA methyltransferase NSUN4

    See identical proteins and their annotated locations for NP_001100148.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474008
    UniProtKB/TrEMBL
    A6JZ58, D4A099, D4A5A7
    Related
    ENSRNOP00000016714.5, ENSRNOT00000016714.7
    Conserved Domains (1) summary
    cl17173
    Location:163 → 322
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    134749024..134773630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109593.2 → XP_038965521.1  5-methylcytosine rRNA methyltransferase NSUN4 isoform X1

    Conserved Domains (1) summary
    TIGR00446
    Location:3 → 174
    nop2p; NOL1/NOP2/sun family putative RNA methylase
Nucleotide Protein Strain
Heading Accession and Version

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