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Mycl MYCL proto-oncogene, bHLH transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 298506, updated on 2-Nov-2024

Summary

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Official Symbol
Myclprovided by RGD
Official Full Name
MYCL proto-oncogene, bHLH transcription factorprovided by RGD
Primary source
RGD:1588591
See related
EnsemblRapid:ENSRNOG00000014259 AllianceGenome:RGD:1588591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lmyc1; Mycl1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of inner ear auditory receptor cell differentiation. Predicted to be located in chromosome and nucleoplasm. Orthologous to several human genes including MYCL (MYCL proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 61.3), Thymus (RPKM 34.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mycl in Genome Data Viewer
Location:
5q36
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (140559843..140566704)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135274713..135281584)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (140691947..140698837)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cyclase associated actin cytoskeleton regulatory protein 1 Neighboring gene uncharacterized LOC100909490 Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene tRNA isopentenyltransferase 1 Neighboring gene bone morphogenetic protein 8b Neighboring gene 3-oxoacid CoA transferase 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. N-Myc and L-Myc are essential for hair cell formation but not maintenance. Kopecky BJ, et al. Brain Res, 2012 Nov 12. PMID 23022312, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of inner ear auditory receptor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein L-Myc
Names
Avian myelocytomatosis viral (v-myc) related oncogene homolog 1, lung carcinoma derived (Lmyc)
protein L-Myc-1
v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191763.3 → NP_001178692.1  protein L-Myc isoform 1

    See identical proteins and their annotated locations for NP_001178692.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6IS13
    Conserved Domains (2) summary
    cd00083
    Location:284 → 338
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam01056
    Location:2 → 219
    Myc_N; Myc amino-terminal region

  2. NM_001411603.2 → NP_001398532.1  protein L-Myc isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    G3V7T4
    Related
    ENSRNOP00000019101.4, ENSRNOT00000019101.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    140559843..140566704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238795.5 → XP_006238857.1  protein L-Myc isoform X2

    See identical proteins and their annotated locations for XP_006238857.1

    UniProtKB/TrEMBL
    A6IS13
    Conserved Domains (2) summary
    cd00083
    Location:284 → 338
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam01056
    Location:2 → 219
    Myc_N; Myc amino-terminal region

  2. XM_039109610.2 → XP_038965538.1  protein L-Myc isoform X1

    Conserved Domains (2) summary
    cd11457
    Location:310 → 398
    bHLHzip_L-Myc; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins
    pfam01056
    Location:26 → 248
    Myc_N; Myc amino-terminal region
Nucleotide Protein Strain
Heading Accession and Version

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