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Cnksr1 connector enhancer of kinase suppressor of Ras 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298545, updated on 10-Jul-2024

Summary

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Official Symbol
Cnksr1provided by RGD
Official Full Name
connector enhancer of kinase suppressor of Ras 1provided by RGD
Primary source
RGD:1311879
See related
EnsemblRapid:ENSRNOG00000022838 AllianceGenome:RGD:1311879
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein-macromolecule adaptor activity. Predicted to act upstream of or within Rho protein signal transduction. Predicted to be located in cell cortex. Orthologous to human CNKSR1 (connector enhancer of kinase suppressor of Ras 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 58.6), Kidney (RPKM 39.3) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cnksr1 in Genome Data Viewer
Location:
5q36
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151731222..151742049, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (146447495..146458332, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (152447348..152458005, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene Uromoduilin-like Neighboring gene cation channel, sperm associated 4 Neighboring gene uncharacterized LOC120103003 Neighboring gene zinc finger protein 593 Neighboring gene similar to human chromosome 1 open reading frame 230

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. Rabizadeh S, et al. J Biol Chem, 2004 Jul 9. PMID 15075335
  2. An ATIPical family of angiotensin II AT2 receptor-interacting proteins. Rodrigues-Ferreira S, et al. Trends Endocrinol Metab, 2010 Nov. PMID 20889352
  3. Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. Jaffe AB, et al. Mol Cell Biol, 2004 Feb. PMID 14749388, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124829

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in synapse organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
connector enhancer of kinase suppressor of ras 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039011.1 → NP_001034100.1  connector enhancer of kinase suppressor of ras 1

    See identical proteins and their annotated locations for NP_001034100.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099788
    UniProtKB/TrEMBL
    A6IT10, Q499S0
    Conserved Domains (6) summary
    smart00454
    Location:4 → 69
    SAM; Sterile alpha motif
    cd00992
    Location:205 → 273
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01260
    Location:381 → 494
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:395 → 491
    PH; PH domain
    pfam10534
    Location:78 → 161
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    cl15755
    Location:4 → 70
    SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    151731222..151742049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287451.1 → XP_063143521.1  connector enhancer of kinase suppressor of ras 1 isoform X3

    UniProtKB/TrEMBL
    G3V8W8
    Related
    ENSRNOP00000029346.4, ENSRNOT00000031225.6

  2. XM_039109635.1 → XP_038965563.1  connector enhancer of kinase suppressor of ras 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AI85
    Related
    ENSRNOP00000095433.2, ENSRNOT00000097555.2
    Conserved Domains (4) summary
    cd00992
    Location:300 → 364
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01260
    Location:472 → 585
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam10534
    Location:142 → 225
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    cl15755
    Location:68 → 134
    SAM_superfamily; SAM (Sterile alpha motif )

  3. XM_063287450.1 → XP_063143520.1  connector enhancer of kinase suppressor of ras 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AI85

  4. XM_063287452.1 → XP_063143522.1  connector enhancer of kinase suppressor of ras 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AI85

  5. XM_063287453.1 → XP_063143523.1  connector enhancer of kinase suppressor of ras 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AN25, A6IT10
Nucleotide Protein Strain
Heading Accession and Version

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