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Tcea3 transcription elongation factor A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298559, updated on 2-Nov-2024

Summary

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Official Symbol
Tcea3provided by RGD
Official Full Name
transcription elongation factor A3provided by RGD
Primary source
RGD:1311369
See related
EnsemblRapid:ENSRNOG00000011794 AllianceGenome:RGD:1311369
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human TCEA3 (transcription elongation factor A3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 516.6), Kidney (RPKM 142.0) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tcea3 in Genome Data Viewer
Location:
5q36
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153760401..153792934)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148476941..148509452)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154598765..154634687)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479041 Neighboring gene E2F transcription factor 2 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene uncharacterized LOC134487016 Neighboring gene immunoglobulin heavy chain 6 like 1 Neighboring gene zinc finger protein 46

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Control of transcriptional elongation. Kwak H, et al. Annu Rev Genet, 2013. PMID 24050178, Free PMC Article
  2. Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Nishiyama A, et al. Cell Stem Cell, 2009 Oct 2. PMID 19796622, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108819

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription elongation factor A protein 3
Names
transcription elongation factor A (SII), 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015008.1 → NP_001015008.1  transcription elongation factor A protein 3

    See identical proteins and their annotated locations for NP_001015008.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091180
    UniProtKB/TrEMBL
    F7EY03, Q5BK74
    Conserved Domains (4) summary
    cd00183
    Location:4 → 80
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    cd13749
    Location:301 → 347
    Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
    TIGR01385
    Location:5 → 348
    TFSII; transcription elongation factor S-II
    pfam07500
    Location:185 → 292
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    153760401..153792934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287455.1 → XP_063143525.1  transcription elongation factor A protein 3 isoform X1

    UniProtKB/TrEMBL
    Q5BK74
    Related
    ENSRNOP00000015776.6, ENSRNOT00000015776.8
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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