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Miip migration and invasion inhibitory protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 298643, updated on 2-Nov-2024

Summary

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Symbol
Miipprovided by RGD
Full Name
migration and invasion inhibitory proteinprovided by RGD
Primary source
RGD:1587376
See related
EnsemblRapid:ENSRNOG00000024139 AllianceGenome:RGD:1587376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Iip45
Summary
Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of cell migration. Orthologous to human MIIP (migration and invasion inhibitory protein). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Note: GeneIDs 100911456 and 298643 are annotated independently on Rnor_6.0 but may be redundant loci. [06 Feb 2015]
Expression
Biased expression in Testes (RPKM 119.7), Thymus (RPKM 109.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Miip in Genome Data Viewer
Location:
5q36
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (163575689..163582739, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (158292510..158299533, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (164672464..164679503, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene reduced expression 2 like 3 Neighboring gene zinc finger protein 933 Neighboring gene mitofusin 2 Neighboring gene uncharacterized LOC134487036

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
migration and invasion-inhibitory protein
Names
IGFBP-2-Binding Protein, IIp45
invasion-inhibitory protein 45
migration and invasion-inhibitory protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017450.2 → NP_001017450.1  migration and invasion-inhibitory protein

    See identical proteins and their annotated locations for NP_001017450.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q6AYH0
    Related
    ENSRNOP00000032889.3, ENSRNOT00000035695.7
    Conserved Domains (1) summary
    pfam15734
    Location:48 → 379
    MIIP; Migration and invasion-inhibitory

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    163575689..163582739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287475.1 → XP_063143545.1  migration and invasion-inhibitory protein isoform X1

    Related
    ENSRNOP00000101624.1, ENSRNOT00000160762.1

  2. XM_006239379.4 → XP_006239441.1  migration and invasion-inhibitory protein isoform X2

    See identical proteins and their annotated locations for XP_006239441.1

    UniProtKB/Swiss-Prot
    Q6AYH0
    UniProtKB/TrEMBL
    C0KL24
    Conserved Domains (1) summary
    pfam15734
    Location:42 → 381
    MIIP; Migration and invasion-inhibitory

  3. XM_063287479.1 → XP_063143549.1  migration and invasion-inhibitory protein isoform X1

  4. XM_006239381.4 → XP_006239443.1  migration and invasion-inhibitory protein isoform X2

    See identical proteins and their annotated locations for XP_006239443.1

    UniProtKB/Swiss-Prot
    Q6AYH0
    UniProtKB/TrEMBL
    C0KL24
    Conserved Domains (1) summary
    pfam15734
    Location:42 → 381
    MIIP; Migration and invasion-inhibitory

  5. XM_006239380.5 → XP_006239442.1  migration and invasion-inhibitory protein isoform X2

    See identical proteins and their annotated locations for XP_006239442.1

    UniProtKB/Swiss-Prot
    Q6AYH0
    UniProtKB/TrEMBL
    C0KL24
    Conserved Domains (1) summary
    pfam15734
    Location:42 → 381
    MIIP; Migration and invasion-inhibitory

  6. XM_063287474.1 → XP_063143544.1  migration and invasion-inhibitory protein isoform X1

  7. XM_063287478.1 → XP_063143548.1  migration and invasion-inhibitory protein isoform X1

  8. XM_063287476.1 → XP_063143546.1  migration and invasion-inhibitory protein isoform X1

  9. XM_063287477.1 → XP_063143547.1  migration and invasion-inhibitory protein isoform X1

  10. XM_039109695.2 → XP_038965623.1  migration and invasion-inhibitory protein isoform X2

    UniProtKB/Swiss-Prot
    Q6AYH0
    UniProtKB/TrEMBL
    C0KL24
    Conserved Domains (1) summary
    pfam15734
    Location:42 → 381
    MIIP; Migration and invasion-inhibitory

  11. XM_063287480.1 → XP_063143550.1  migration and invasion-inhibitory protein isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYH0.2 GenPept UniProtKB/Swiss-Prot:Q6AYH0

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