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Atad3a ATPase family, AAA domain containing 3A [ Rattus norvegicus (Norway rat) ]

Gene ID: 298682, updated on 2-Nov-2024

Summary

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Official Symbol
Atad3aprovided by RGD
Official Full Name
ATPase family, AAA domain containing 3Aprovided by RGD
Primary source
RGD:1305964
See related
EnsemblRapid:ENSRNOG00000018118 AllianceGenome:RGD:1305964
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atad3
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including antiviral innate immune response; mitochondrion organization; and regulation of cell growth. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Harel-Yoon syndrome and neonatal lethal pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome. Orthologous to several human genes including ATAD3A (ATPase family AAA domain containing 3A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 125.0), Adrenal (RPKM 122.4) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Atad3a in Genome Data Viewer
Location:
5q36
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171632545..171652725, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166350302..166370492, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173189590..173209809, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 10 Neighboring gene SSU72 homolog, RNA polymerase II CTD phosphatase Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 240 Neighboring gene ATPase family, AAA domain containing 3A, opposite strand Neighboring gene von Willebrand factor A domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ATPase family AAA domain-containing 3A is a novel anti-apoptotic factor in lung adenocarcinoma cells. Fang HY, et al. J Cell Sci, 2010 Apr 1. PMID 20332122
  2. Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3. Issop L, et al. Endocrinology, 2015 Jan. PMID 25375035
  3. Atad3 function is essential for early post-implantation development in the mouse. Goller T, et al. PLoS One, 2013. PMID 23372768, Free PMC Article
  4. ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects. Zhao Y, et al. Nat Commun, 2019 Mar 26. PMID 30914652, Free PMC Article
  5. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124646

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of HRI-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of HRI-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in antiviral innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial nucleoid IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATPase family AAA domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034922.1 → NP_001030094.1  ATPase family AAA domain-containing protein 3

    See identical proteins and their annotated locations for NP_001030094.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105762
    UniProtKB/Swiss-Prot
    Q3KRE0
    UniProtKB/TrEMBL
    A0A8I6AD85, A6IUR9
    Related
    ENSRNOP00000046842.3, ENSRNOT00000045053.5
    Conserved Domains (2) summary
    pfam12037
    Location:27 → 285
    DUF3523; Domain of unknown function (DUF3523)
    cd19512
    Location:323 → 472
    RecA-like_ATAD3-like; ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    171632545..171652725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001837838.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KRE0.1 GenPept UniProtKB/Swiss-Prot:Q3KRE0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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