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Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298748, updated on 2-Nov-2024

Summary

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Official Symbol
Ndufaf7provided by RGD
Official Full Name
NADH:ubiquinone oxidoreductase complex assembly factor 7provided by RGD
Primary source
RGD:1311578
See related
EnsemblRapid:ENSRNOG00000005279 AllianceGenome:RGD:1311578
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311578
Summary
Predicted to enable enzyme binding activity and protein-arginine omega-N symmetric methyltransferase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly and peptidyl-arginine methylation, to symmetrical-dimethyl arginine. Predicted to be active in mitochondrion. Orthologous to human NDUFAF7 (NADH:ubiquinone oxidoreductase complex assembly factor 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 114.8), Heart (RPKM 94.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ndufaf7 in Genome Data Viewer
Location:
6q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (21860788..21871965, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (16108630..16119810, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (1534594..1545831)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S17, pseudogene 9 Neighboring gene protein kinase D3 Neighboring gene CCAAT/enhancer binding protein zeta Neighboring gene CEBPZ opposite strand Neighboring gene heterogeneous nuclear ribonucleoprotein F, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NDUFAF7 methylates arginine 85 in the NDUFS2 subunit of human complex I. Rhein VF, et al. J Biol Chem, 2013 Nov 15. PMID 24089531, Free PMC Article
  2. The arginine methyltransferase NDUFAF7 is essential for complex I assembly and early vertebrate embryogenesis. Zurita Rendón O, et al. Hum Mol Genet, 2014 Oct 1. PMID 24838397, Free PMC Article
  3. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
  4. MidA is a putative methyltransferase that is required for mitochondrial complex I function. Carilla-Latorre S, et al. J Cell Sci, 2010 May 15. PMID 20406883
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94867

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-arginine omega-N symmetric methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine omega-N symmetric methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-arginine omega-N symmetric methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-arginine methylation, to symmetrical-dimethyl arginine ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-arginine methylation, to symmetrical-dimethyl arginine ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein arginine methyltransferase NDUFAF7, mitochondrial
Names
NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NADH dehydrogenase [ubiquinone] complex I, assembly factor 7
protein midA homolog, mitochondrial
NP_001008319.1
XP_038967822.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008318.1 → NP_001008319.1  protein arginine methyltransferase NDUFAF7, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001008319.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083810
    UniProtKB/Swiss-Prot
    Q5XI79
    UniProtKB/TrEMBL
    A0A8L2UHW1, A6H9U5
    Related
    ENSRNOP00000084400.2, ENSRNOT00000109935.2
    Conserved Domains (2) summary
    COG1565
    Location:46 → 402
    MidA; SAM-dependent methyltransferase, MidA family [General function prediction only]
    pfam02636
    Location:95 → 349
    Methyltransf_28; Putative S-adenosyl-L-methionine-dependent methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    21860788..21871965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111894.2 → XP_038967822.1  protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I6A175
    Related
    ENSRNOP00000098713.1, ENSRNOT00000149624.1
    Conserved Domains (1) summary
    pfam02636
    Location:131 → 385
    Methyltransf_28; Putative S-adenosyl-L-methionine-dependent methyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XI79.1 GenPept UniProtKB/Swiss-Prot:Q5XI79

Gene LinkOut

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