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Cox7a2l cytochrome c oxidase subunit 7A2 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 298762, updated on 2-Nov-2024

Summary

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Official Symbol
Cox7a2lprovided by RGD
Official Full Name
cytochrome c oxidase subunit 7A2 likeprovided by RGD
Primary source
RGD:1306111
See related
EnsemblRapid:ENSRNOG00000004526 AllianceGenome:RGD:1306111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Predicted to be located in mitochondrion and nucleolus. Predicted to be part of respiratory chain complex. Orthologous to human COX7A2L (cytochrome c oxidase subunit 7A2 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 975.2), Thymus (RPKM 882.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cox7a2l in Genome Data Viewer
Location:
6q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (16936574..16950797)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (11184064..11198287)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (6695807..6709790, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479097 Neighboring gene uncharacterized LOC120093197 Neighboring gene uncharacterized LOC134479098 Neighboring gene EMAP like 4 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 10 Neighboring gene uncharacterized LOC102556624

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle. Ikeda K, et al. Nat Commun, 2013. PMID 23857330
  2. Supercomplex assembly determines electron flux in the mitochondrial electron transport chain. Lapuente-Brun E, et al. Science, 2013 Jun 28. PMID 23812712
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respirasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respirasome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of oxidative phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 7A2 like
Names
cytochrome c oxidase subunit VIIa polypeptide 2 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106704.2 → NP_001100174.1  cytochrome c oxidase subunit 7A2 like isoform 1

    See identical proteins and their annotated locations for NP_001100174.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6H9M6, D3ZYX8
    Conserved Domains (1) summary
    cd00928
    Location:62 → 115
    Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. NM_001399338.1 → NP_001386267.1  cytochrome c oxidase subunit 7A2 like isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  3. NM_001399340.1 → NP_001386269.1  cytochrome c oxidase subunit 7A2 like isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    B2RYT5
    Related
    ENSRNOP00000063344.2, ENSRNOT00000065464.4
    Conserved Domains (1) summary
    cd00928
    Location:55 → 108
    Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  4. NM_001399341.1 → NP_001386270.1  cytochrome c oxidase subunit 7A2 like isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RNA

  1. NR_174177.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    Related
    ENSRNOT00000105892.2

  2. NR_174178.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  3. NR_174179.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  4. NR_174180.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  5. NR_174181.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    16936574..16950797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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