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Rab3ip RAB3A interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 29885, updated on 11-Apr-2024

Summary

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Official Symbol
Rab3ipprovided by RGD
Official Full Name
RAB3A interacting proteinprovided by RGD
Primary source
RGD:620650
See related
Ensembl:ENSRNOG00000005362 AllianceGenome:RGD:620650
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RABIN3
Summary
Enables GTPase binding activity and guanyl-nucleotide exchange factor activity. Involved in negative regulation of filopodium assembly. Located in cytosol; perinuclear region of cytoplasm; and proximal dendrite. Colocalizes with Golgi apparatus. Orthologous to human RAB3IP (RAB3A interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 204.7), Thymus (RPKM 120.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q22
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (54417418..54461253, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52531461..52575295, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (59927486..59971518, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene myelin regulatory factor-like Neighboring gene H3.3 histone A, pseudogene 5 Neighboring gene bestrophin 3 Neighboring gene uncharacterized LOC134479874 Neighboring gene uncharacterized LOC120093598

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. Hattula K, et al. Mol Biol Cell, 2002 Sep. PMID 12221131, Free PMC Article
  2. Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11. Vetter M, et al. Nat Struct Mol Biol, 2015 Sep. PMID 26258637
  3. RabGEFs are a major determinant for specific Rab membrane targeting. Blümer J, et al. J Cell Biol, 2013 Feb 4. PMID 23382462, Free PMC Article
  4. NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15. Chiba S, et al. EMBO J, 2013 Mar 20. PMID 23435566, Free PMC Article
  5. Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A. Brondyk WH, et al. Mol Cell Biol, 1995 Mar. PMID 7532276, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to motile cilium ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to organelle ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi to plasma membrane transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in proximal dendrite IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rab-3A-interacting protein
Names
SSX2-interacting protein
rab3A-interacting protein
rabin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017313.3 → NP_059009.2  rab-3A-interacting protein

    See identical proteins and their annotated locations for NP_059009.2

    Status: PROVISIONAL

    Source sequence(s)
    BC127500
    UniProtKB/Swiss-Prot
    A1L127, Q62739
    UniProtKB/TrEMBL
    A0A0G2K1B4
    Related
    ENSRNOP00000007258.4, ENSRNOT00000007258.6
    Conserved Domains (3) summary
    COG4372
    Location:98 → 240
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    pfam06428
    Location:173 → 241
    Sec2p; GDP/GTP exchange factor Sec2p
    cd21068
    Location:266 → 458
    Rab11BD_RAB3IP; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    54417418..54461253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241357.5 → XP_006241419.1  rab-3A-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006241419.1

    UniProtKB/Swiss-Prot
    A1L127, Q62739
    UniProtKB/TrEMBL
    A0A0G2K1B4
    Conserved Domains (3) summary
    COG4372
    Location:98 → 240
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    pfam06428
    Location:173 → 241
    Sec2p; GDP/GTP exchange factor Sec2p
    cd21068
    Location:266 → 458
    Rab11BD_RAB3IP; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP)

  2. XM_006241360.4 → XP_006241422.1  rab-3A-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006241422.1

    UniProtKB/Swiss-Prot
    A1L127, Q62739
    UniProtKB/TrEMBL
    A0A0G2K1B4
    Conserved Domains (3) summary
    COG4372
    Location:98 → 240
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    pfam06428
    Location:173 → 241
    Sec2p; GDP/GTP exchange factor Sec2p
    cd21068
    Location:266 → 458
    Rab11BD_RAB3IP; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP)

  3. XM_039078619.1 → XP_038934547.1  rab-3A-interacting protein isoform X5

    UniProtKB/TrEMBL
    A6IGQ0
    Conserved Domains (1) summary
    cd21068
    Location:60 → 252
    Rab11BD_RAB3IP; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP)

  4. XM_063263145.1 → XP_063119215.1  rab-3A-interacting protein isoform X5

  5. XM_063263144.1 → XP_063119214.1  rab-3A-interacting protein isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZML7

  6. XM_063263143.1 → XP_063119213.1  rab-3A-interacting protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6AR50

  7. XM_063263142.1 → XP_063119212.1  rab-3A-interacting protein isoform X1

    UniProtKB/Swiss-Prot
    A1L127, Q62739

  8. XM_008765383.4 → XP_008763605.1  rab-3A-interacting protein isoform X4

    UniProtKB/TrEMBL
    A6IGQ0
    Conserved Domains (1) summary
    pfam06428
    Location:22 → 103
    Sec2p; GDP/GTP exchange factor Sec2p

  9. XM_039078620.2 → XP_038934548.1  rab-3A-interacting protein isoform X6

    Conserved Domains (1) summary
    cl41767
    Location:1 → 182
    Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62739.2 GenPept UniProtKB/Swiss-Prot:Q62739

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