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Dnajc27 DnaJ heat shock protein family (Hsp40) member C27 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298859, updated on 2-Nov-2024

Summary

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Official Symbol
Dnajc27provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member C27provided by RGD
Primary source
RGD:1564414
See related
EnsemblRapid:ENSRNOG00000003988 AllianceGenome:RGD:1564414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rbj
Summary
Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in nucleus. Orthologous to human DNAJC27 (DnaJ heat shock protein family (Hsp40) member C27). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 207.7), Testes (RPKM 92.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnajc27 in Genome Data Viewer
Location:
6q14
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (32788215..32842418)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (27068713..27098449)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (28515054..28544756)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene proopiomelanocortin Neighboring gene EFR3 homolog B Neighboring gene uncharacterized LOC120103495 Neighboring gene cytochrome c oxidase subunit 7B, pseudogene 3 Neighboring gene general transcription factor IIH subunit 5-like Neighboring gene adenylate cyclase 3 Neighboring gene centromere protein O Neighboring gene peptidyl-tRNA hydrolase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression. Chen T, et al. Cancer Cell, 2014 May 12. PMID 24746703
  2. RJLs: a new family of Ras-related GTP-binding proteins. Nepomuceno-Silva JL, et al. Gene, 2004 Mar 3. PMID 14980719
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 27
Names
DnaJ (Hsp40) homolog, subfamily C, member 27
rab and DnaJ domain containing
rab and DnaJ domain-containing protein
NP_996727.2
XP_038967845.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_206845.2 → NP_996727.2  dnaJ homolog subfamily C member 27

    See identical proteins and their annotated locations for NP_996727.2

    Status: VALIDATED

    Source sequence(s)
    BK001286, DY314277, JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q6IML7
    UniProtKB/TrEMBL
    A6HAH0
    Conserved Domains (2) summary
    cd06257
    Location:217 → 264
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    cd04119
    Location:17 → 184
    RJL; Rab GTPase family J-like (RabJ-like)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    32788215..32842418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111917.2 → XP_038967845.1  dnaJ homolog subfamily C member 27 isoform X1

    UniProtKB/Swiss-Prot
    Q6IML7
    UniProtKB/TrEMBL
    A6HAH0
    Related
    ENSRNOP00000005317.2, ENSRNOT00000005317.7
    Conserved Domains (2) summary
    cd06257
    Location:217 → 264
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    cd04119
    Location:17 → 184
    RJL; Rab GTPase family J-like (RabJ-like)

RNA

  1. XR_010052060.1 RNA Sequence

  2. XR_354626.5 RNA Sequence

    Related
    ENSRNOT00000081141.3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IML7.1 GenPept UniProtKB/Swiss-Prot:Q6IML7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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