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Klhl29 kelch-like family member 29 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298867, updated on 2-Nov-2024

Summary

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Official Symbol
Klhl29provided by RGD
Official Full Name
kelch-like family member 29provided by RGD
Primary source
RGD:1311076
See related
EnsemblRapid:ENSRNOG00000005371 AllianceGenome:RGD:1311076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kbtbd9
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL29 (kelch like family member 29). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 22.6), Brain (RPKM 20.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhl29 in Genome Data Viewer
Location:
6q14
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (33805922..34110055, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (28086489..28390647, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (29178858..29483460, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene UBX domain protein 2A Neighboring gene ATPase family, AAA domain containing 2B Neighboring gene uncharacterized LOC134479334 Neighboring gene uncharacterized LOC120103500 Neighboring gene uncharacterized LOC134479335 Neighboring gene uncharacterized LOC103692581 Neighboring gene uncharacterized LOC120103501 Neighboring gene uncharacterized LOC120103502

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC189300

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kelch-like protein 29
Names
kelch repeat and BTB (POZ) domain containing 9
kelch-like 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106713.3 → NP_001100183.1  kelch-like protein 29

    See identical proteins and their annotated locations for NP_001100183.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AE73, A6HAK4, D4AEF4
    Related
    ENSRNOP00000007160.5, ENSRNOT00000007160.10
    Conserved Domains (5) summary
    PHA03098
    Location:333 → 860
    PHA03098; kelch-like protein; Provisional
    PHA03247
    Location:22 → 290
    PHA03247; large tegument protein UL36; Provisional
    sd00038
    Location:673 → 716
    Kelch; KELCH repeat [structural motif]
    cd18468
    Location:432 → 533
    BACK_KLHL29_KBTBD9; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29)
    cl38908
    Location:312 → 438
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    33805922..34110055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594072.3 → XP_017449561.1  kelch-like protein 29 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AE73, A6HAK4, D4AEF4
    Conserved Domains (5) summary
    PHA03098
    Location:333 → 860
    PHA03098; kelch-like protein; Provisional
    PHA03247
    Location:22 → 290
    PHA03247; large tegument protein UL36; Provisional
    sd00038
    Location:673 → 716
    Kelch; KELCH repeat [structural motif]
    cd18468
    Location:432 → 533
    BACK_KLHL29_KBTBD9; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29)
    cl38908
    Location:312 → 438
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  2. XM_006239857.5 → XP_006239919.1  kelch-like protein 29 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AE73
    Conserved Domains (6) summary
    smart00612
    Location:875 → 923
    Kelch; Kelch domain
    PHA03098
    Location:386 → 913
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:726 → 769
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:372 → 480
    BTB; BTB/POZ domain
    pfam01344
    Location:725 → 770
    Kelch_1; Kelch motif
    pfam07707
    Location:489 → 590
    BACK; BTB And C-terminal Kelch

  3. XM_039111920.2 → XP_038967848.1  kelch-like protein 29 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AE73, A6HAK4, D4AEF4
    Conserved Domains (5) summary
    PHA03098
    Location:333 → 860
    PHA03098; kelch-like protein; Provisional
    PHA03247
    Location:22 → 290
    PHA03247; large tegument protein UL36; Provisional
    sd00038
    Location:673 → 716
    Kelch; KELCH repeat [structural motif]
    cd18468
    Location:432 → 533
    BACK_KLHL29_KBTBD9; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29)
    cl38908
    Location:312 → 438
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  4. XM_039111919.2 → XP_038967847.1  kelch-like protein 29 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AE73
    Conserved Domains (5) summary
    PHA03098
    Location:409 → 936
    PHA03098; kelch-like protein; Provisional
    PHA03247
    Location:98 → 366
    PHA03247; large tegument protein UL36; Provisional
    sd00038
    Location:749 → 792
    Kelch; KELCH repeat [structural motif]
    cd18468
    Location:508 → 609
    BACK_KLHL29_KBTBD9; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29)
    cl38908
    Location:388 → 514
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  5. XM_008764550.4 → XP_008762772.1  kelch-like protein 29 isoform X4

    See identical proteins and their annotated locations for XP_008762772.1

    UniProtKB/TrEMBL
    A0A8I6AE73, A6HAK4, D4AEF4
    Conserved Domains (5) summary
    PHA03098
    Location:333 → 860
    PHA03098; kelch-like protein; Provisional
    PHA03247
    Location:22 → 290
    PHA03247; large tegument protein UL36; Provisional
    sd00038
    Location:673 → 716
    Kelch; KELCH repeat [structural motif]
    cd18468
    Location:432 → 533
    BACK_KLHL29_KBTBD9; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29)
    cl38908
    Location:312 → 438
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  6. XM_017594070.3 → XP_017449559.1  kelch-like protein 29 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AE73
    Related
    ENSRNOP00000105594.1, ENSRNOT00000161516.1
Nucleotide Protein Strain
Heading Accession and Version

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