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GNL2 G protein nucleolar 2 [ Homo sapiens (human) ]

Gene ID: 29889, updated on 14-Nov-2024

Summary

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Official Symbol
GNL2provided by HGNC
Official Full Name
G protein nucleolar 2provided by HGNC
Primary source
HGNC:HGNC:29925
See related
Ensembl:ENSG00000134697 MIM:609365; AllianceGenome:HGNC:29925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NGP1; Nog2; Nug2; Ngp-1; HUMAUANTIG
Summary
Enables RNA binding activity. Predicted to be involved in ribosome biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 19.5), bone marrow (RPKM 14.5) and 25 other tissues See more
Orthologs
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Genomic context

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See GNL2 in Genome Data Viewer
Location:
1p34.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (37566816..37595937, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (37431567..37460686, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38032417..38061538, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Smad nuclear interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38021148-38022118 Neighboring gene Sharpr-MPRA regulatory region 12224 Neighboring gene ferritin heavy chain 1 pseudogene 1 Neighboring gene ribosomal protein S27 pseudogene 9 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:38033816-38035015 Neighboring gene dynein axonemal light intermediate chain 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:38041731-38042930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 771 Neighboring gene Sharpr-MPRA regulatory region 1638 Neighboring gene Sharpr-MPRA regulatory region 1490 Neighboring gene R-spondin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38096333-38096846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38098855-38099382 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38099911-38100438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38100439-38100965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38126219-38126852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38128815-38129348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38129349-38129881 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38132271-38132990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38156929-38157439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38157440-38157949 Neighboring gene AFG2 interacting ribosome maturation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning of a novel nucleolar guanosine 5'-triphosphate binding protein autoantigen from a breast tumor. Racevskis J, et al. Cell Growth Differ, 1996 Feb. PMID 8822211
  2. Functional analysis of the 1p34.3 risk locus implicates GNL2 in high-grade serous ovarian cancer. Nakamura K, et al. Am J Hum Genet, 2022 Jan 6. PMID 34965383, Free PMC Article
  3. Study of the G Protein Nucleolar 2 Value in Liver Hepatocellular Carcinoma Treatment and Prognosis. Dong Y, et al. Biomed Res Int, 2021. PMID 34337013, Free PMC Article
  4. Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals. Casadio A, et al. EMBO Rep, 2015 Jan. PMID 25452588, Free PMC Article
  5. Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1. Datta D, et al. J Biol Chem, 2015 Aug 28. PMID 26203195, Free PMC Article

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional analysis of the 1p34.3 risk locus implicates GNL2 in high-grade serous ovarian cancer.
    Title: Functional analysis of the 1p34.3 risk locus implicates GNL2 in high-grade serous ovarian cancer.
  2. Study of the G Protein Nucleolar 2 Value in Liver Hepatocellular Carcinoma Treatment and Prognosis.
    Title: Study of the G Protein Nucleolar 2 Value in Liver Hepatocellular Carcinoma Treatment and Prognosis.
  3. NGP-1 promotes cell cycle progression through the activation of the p53/p21(Cip-1/Waf1) pathway.
    Title: Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1.
  4. GNL2 and SEC13 are required for nonsense-mediated mRNA decay pathway in human cells.
    Title: Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ40906

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables GTPase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables RNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
nucleolar GTP-binding protein 2
Names
autoantigen NGP-1
guanine nucleotide binding protein-like 2 (nucleolar)
novel nucleolar guanosine 5'-triphosphate binding protein autoantigen
nucleolar G-protein gene 1
nucleolar GTPase
nucleostemin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323623.2 → NP_001310552.1  nucleolar GTP-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL034379, AL513220
    Conserved Domains (4) summary
    cd01858
    Location:209 → 433
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    COG0711
    Location:661 → 756
    AtpF; FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]
    COG1161
    Location:190 → 534
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    pfam08153
    Location:44 → 174
    NGP1NT; NGP1NT (NUC091) domain

  2. NM_001323624.2 → NP_001310553.1  nucleolar GTP-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL034379, AL513220

  3. NM_013285.3 → NP_037417.1  nucleolar GTP-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_037417.1

    Status: VALIDATED

    Source sequence(s)
    AA766044, BC009250, DB452094
    Consensus CDS
    CCDS421.1
    UniProtKB/Swiss-Prot
    Q13823, Q9BWN7
    UniProtKB/TrEMBL
    Q5T0F3
    Related
    ENSP00000362153.3, ENST00000373062.8
    Conserved Domains (4) summary
    cd01858
    Location:209 → 365
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    COG0711
    Location:593 → 688
    AtpF; FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]
    COG1160
    Location:316 → 421
    Der; Predicted GTPases [General function prediction only]
    pfam08153
    Location:43 → 174
    NGP1NT; NGP1NT (NUC091) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    37566816..37595937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446591.2 → XP_024302359.1  nucleolar GTP-binding protein 2 isoform X1

    Conserved Domains (3) summary
    cd01858
    Location:50 → 274
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    cl26335
    Location:59 → 365
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    cl28522
    Location:502 → 597
    AtpF; FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    37431567..37460686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336183.1 → XP_054192158.1  nucleolar GTP-binding protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13823.1 GenPept UniProtKB/Swiss-Prot:Q13823

Gene LinkOut

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