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G2e3 G2/M-phase specific E3 ubiquitin protein ligase [ Rattus norvegicus (Norway rat) ]

Gene ID: 299002, updated on 17-Aug-2024

Summary

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Official Symbol
G2e3provided by RGD
Official Full Name
G2/M-phase specific E3 ubiquitin protein ligaseprovided by RGD
Primary source
RGD:1310263
See related
EnsemblRapid:ENSRNOG00000004232 AllianceGenome:RGD:1310263
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310263
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to act upstream of or within blastocyst development; negative regulation of intrinsic apoptotic signaling pathway; and protein polyubiquitination. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in nucleus. Orthologous to human G2E3 (G2/M-phase specific E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 99.4), Spleen (RPKM 73.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See G2e3 in Genome Data Viewer
Location:
6q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (74498801..74530703)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (68763847..68795305)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (72092148..72123878)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479382 Neighboring gene uncharacterized LOC134479383 Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 3 Neighboring gene sec1 family domain containing 1 Neighboring gene uncharacterized LOC134479180

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. G2E3 is a dual function ubiquitin ligase required for early embryonic development. Brooks WS, et al. J Biol Chem, 2008 Aug 8. PMID 18511420, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G2/M phase-specific E3 ubiquitin-protein ligase
Names
G2/M-phase specific E3 ubiquitin ligase
NP_001100196.1
XP_006240140.1
XP_006240141.1
XP_017449571.1
XP_017449572.1
XP_063117736.1
XP_063117737.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106726.1 → NP_001100196.1  G2/M phase-specific E3 ubiquitin-protein ligase

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/TrEMBL
    A0A8I5ZML5, A6HBG8, D3ZC11
    Related
    ENSRNOP00000005670.6, ENSRNOT00000005670.9
    Conserved Domains (3) summary
    cd15496
    Location:232 → 285
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:14 → 127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl27008
    Location:365 → 688
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    74498801..74530703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261666.1 → XP_063117736.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZML5, A6HBG8, D3ZC11

  2. XM_006240079.5 → XP_006240141.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZML5, A6HBG8, D3ZC11
    Conserved Domains (3) summary
    cd15496
    Location:232 → 285
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:14 → 127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl27008
    Location:365 → 688
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  3. XM_017594083.3 → XP_017449572.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZML5
    Related
    ENSRNOP00000111434.1, ENSRNOT00000122091.1

  4. XM_063261667.1 → XP_063117737.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZML5

  5. XM_006240078.5 → XP_006240140.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZML5, A6HBG8, D3ZC11
    Conserved Domains (3) summary
    cd15496
    Location:232 → 285
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:14 → 127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl27008
    Location:365 → 688
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  6. XM_017594082.3 → XP_017449571.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZML5
Nucleotide Protein Strain
Heading Accession and Version

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