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Churc1 churchill domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299154, updated on 2-Nov-2024

Summary

Official Symbol
Churc1provided by RGD
Official Full Name
churchill domain containing 1provided by RGD
Primary source
RGD:1305116
See related
EnsemblRapid:ENSRNOG00000007660 AllianceGenome:RGD:1305116
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein farnesyltransferase activity and zinc ion binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be part of microtubule associated complex and protein farnesyltransferase complex. Orthologous to human CHURC1 (churchill domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 469.6), Heart (RPKM 421.8) and 9 other tissues See more
Orthologs
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Genomic context

See Churc1 in Genome Data Viewer
Location:
6q24
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (101203778..101218364)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (95464488..95485208)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (99817439..99831574)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene spectrin, beta, erythrocytic Neighboring gene uncharacterized LOC134479402 Neighboring gene U6 spliceosomal RNA Neighboring gene glutathione peroxidase 2 Neighboring gene RAB15, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein farnesyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in protein farnesylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of microtubule associated complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein farnesyltransferase complex IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106741.2NP_001100211.1  protein Churchill

    See identical proteins and their annotated locations for NP_001100211.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168770
    UniProtKB/TrEMBL
    A0A8I5ZP53, B5DER2, F7FBS9
    Related
    ENSRNOP00000009620.5, ENSRNOT00000009621.9
    Conserved Domains (1) summary
    pfam06573
    Location:1111
    Churchill; Churchill protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    101203778..101218364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112015.2XP_038967943.1  protein Churchill isoform X1

    UniProtKB/TrEMBL
    A0A8I6GKJ2
    Related
    ENSRNOP00000103362.1, ENSRNOT00000150896.1
    Conserved Domains (1) summary
    pfam06573
    Location:160
    Churchill; Churchill protein