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Ylpm1 YLP motif containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299199, updated on 2-Nov-2024

Summary

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Official Symbol
Ylpm1provided by RGD
Official Full Name
YLP motif containing 1provided by RGD
Primary source
RGD:1564946
See related
EnsemblRapid:ENSRNOG00000027317 AllianceGenome:RGD:1564946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zap; Zap3; RGD1564946
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific. Predicted to be involved in regulation of telomere maintenance. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Orthologous to human YLPM1 (YLP motif containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 95.0), Spleen (RPKM 87.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ylpm1 in Genome Data Viewer
Location:
6q31
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110373371..110449578)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104642615..104718508)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108820774..108897209)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene apoptosis resistant E3 ubiquitin protein ligase 1 Neighboring gene Fcf1 rRNA-processing protein Neighboring gene eukaryotic translation initiation factor 2 subunit 2-like Neighboring gene U6 snRNA-associated Sm-like protein LSm5 Neighboring gene small nucleolar RNA U13 Neighboring gene U4 spliceosomal RNA Neighboring gene prospero homeobox 2 Neighboring gene dihydrolipoamide S-succinyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G. Ulke-Lemée A, et al. Biochim Biophys Acta, 2007 Oct. PMID 17890166
  2. Proteomic characterization of protein phosphatase complexes of the mammalian nucleus. Tran HT, et al. Mol Cell Proteomics, 2004 Mar. PMID 14724321
  3. NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines. Peeraully MR, et al. Am J Physiol Endocrinol Metab, 2004 Aug. PMID 15100092
  4. A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Armstrong L, et al. Mech Dev, 2004 Dec. PMID 15511642
  5. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
YLP motif-containing protein 1
Names
Nuclear protein ZAP3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271258.1 → NP_001258187.1  YLP motif-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A0G2K678
    Related
    ENSRNOP00000073707.2, ENSRNOT00000080038.3
    Conserved Domains (1) summary
    pfam13671
    Location:1812 → 1947
    AAA_33; AAA domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    110373371..110449578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112041.2 → XP_038967969.1  YLP motif-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ3, A0A0G2K678
    Related
    ENSRNOP00000070749.2, ENSRNOT00000089683.3
    Conserved Domains (2) summary
    PRK12678
    Location:1059 → 1208
    PRK12678; transcription termination factor Rho; Provisional
    pfam13671
    Location:1821 → 1960
    AAA_33; AAA domain

  2. XM_039112043.2 → XP_038967971.1  YLP motif-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    P0CB49
    Conserved Domains (1) summary
    pfam13671
    Location:1116 → 1255
    AAA_33; AAA domain

  3. XM_039112044.2 → XP_038967972.1  YLP motif-containing protein 1 isoform X3

    UniProtKB/Swiss-Prot
    P0CB49
    UniProtKB/TrEMBL
    F1LQJ1
    Related
    ENSRNOP00000006492.8, ENSRNOT00000006492.9
    Conserved Domains (1) summary
    pfam13671
    Location:1107 → 1246
    AAA_33; AAA domain

RNA

  1. XR_010052072.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CB49.1 GenPept UniProtKB/Swiss-Prot:P0CB49

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials