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Ttll5 tubulin tyrosine ligase like 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299208, updated on 10-Jul-2024

Summary

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Official Symbol
Ttll5provided by RGD
Official Full Name
tubulin tyrosine ligase like 5provided by RGD
Primary source
RGD:1563583
See related
EnsemblRapid:ENSRNOG00000009318 AllianceGenome:RGD:1563583
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563583
Summary
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within fertilization; retina development in camera-type eye; and sperm axoneme assembly. Predicted to be located in several cellular components, including 9+0 non-motile cilium; cytosol; and microtubule organizing center. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in cone-rod dystrophy 19. Orthologous to human TTLL5 (tubulin tyrosine ligase like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 128.7), Brain (RPKM 115.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ttll5 in Genome Data Viewer
Location:
6q31
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (111214048..111431892)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (105483091..105700920)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (109693915..109910479)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351275 Neighboring gene basic leucine zipper ATF-like transcription factor Neighboring gene uncharacterized LOC120103579 Neighboring gene FLVCR choline and putative heme transporter 2 Neighboring gene ergosterol biosynthesis 28 homolog Neighboring gene uncharacterized LOC134479235 Neighboring gene transforming growth factor, beta 3 Neighboring gene intraflagellar transport 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility. Lee GS, et al. J Biol Chem, 2013 May 24. PMID 23558686, Free PMC Article
  2. Mutations in the polyglutamylase gene TTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility. Bedoni N, et al. Hum Mol Genet, 2016 Oct 15. PMID 28173158
  3. Biallelic variants in TTLL5, encoding a tubulin glutamylase, cause retinal dystrophy. Sergouniotis PI, et al. Am J Hum Genet, 2014 May 1. PMID 24791901, Free PMC Article
  4. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049
  5. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TTLL5 was found in the basal body of photoreceptor cells in rat
    Title: Mutations in the polyglutamylase gene TTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fertilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sperm axoneme assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in 9+0 non-motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tubulin polyglutamylase TTLL5
Names
tubulin tyrosine ligase-like family, member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427290.1 → NP_001414219.1  tubulin polyglutamylase TTLL5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6GJ32, D3ZAA1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    111214048..111431892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039113313.2 → XP_038969241.1  tubulin polyglutamylase TTLL5 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ACV1, A0A8I6GJ32
    Related
    ENSRNOP00000092001.1, ENSRNOT00000106283.2
    Conserved Domains (1) summary
    pfam03133
    Location:117 → 395
    TTL; Tubulin-tyrosine ligase family

  2. XM_039113315.2 → XP_038969243.1  tubulin polyglutamylase TTLL5 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GJ32
    Conserved Domains (1) summary
    pfam03133
    Location:117 → 395
    TTL; Tubulin-tyrosine ligase family

  3. XM_063261755.1 → XP_063117825.1  tubulin polyglutamylase TTLL5 isoform X10

    UniProtKB/TrEMBL
    A0A8I6GJ32

  4. XM_039113312.2 → XP_038969240.1  tubulin polyglutamylase TTLL5 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GJ32
    Conserved Domains (1) summary
    pfam03133
    Location:117 → 395
    TTL; Tubulin-tyrosine ligase family

  5. XM_039113317.2 → XP_038969245.1  tubulin polyglutamylase TTLL5 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AL69, A0A8I6GJ32
    Conserved Domains (1) summary
    pfam03133
    Location:117 → 395
    TTL; Tubulin-tyrosine ligase family

  6. XM_039113318.2 → XP_038969246.1  tubulin polyglutamylase TTLL5 isoform X8

    UniProtKB/TrEMBL
    A0A8I6GJ32
    Related
    ENSRNOP00000094535.2, ENSRNOT00000120049.2
    Conserved Domains (1) summary
    pfam03133
    Location:117 → 395
    TTL; Tubulin-tyrosine ligase family

  7. XM_039113314.2 → XP_038969242.1  tubulin polyglutamylase TTLL5 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZKQ8, A0A8I6GJ32
    Related
    ENSRNOP00000078338.1, ENSRNOT00000096708.2
    Conserved Domains (1) summary
    pfam03133
    Location:117 → 395
    TTL; Tubulin-tyrosine ligase family

  8. XM_039113326.2 → XP_038969254.1  tubulin polyglutamylase TTLL5 isoform X15

    Conserved Domains (1) summary
    pfam03133
    Location:117 → 395
    TTL; Tubulin-tyrosine ligase family

  9. XM_039113311.2 → XP_038969239.1  tubulin polyglutamylase TTLL5 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GJ32, D3ZAA1
    Conserved Domains (1) summary
    pfam03133
    Location:117 → 395
    TTL; Tubulin-tyrosine ligase family

  10. XM_063261756.1 → XP_063117826.1  tubulin polyglutamylase TTLL5 isoform X10

    UniProtKB/TrEMBL
    A0A8I6GJ32

  11. XM_039113310.2 → XP_038969238.1  tubulin polyglutamylase TTLL5 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GJ32, D3ZAA1
    Related
    ENSRNOP00000012895.8, ENSRNOT00000012895.9
    Conserved Domains (1) summary
    pfam03133
    Location:117 → 395
    TTL; Tubulin-tyrosine ligase family

  12. XM_039113316.2 → XP_038969244.1  tubulin polyglutamylase TTLL5 isoform X6

    UniProtKB/TrEMBL
    A0A8I6GJ32
    Conserved Domains (1) summary
    pfam03133
    Location:19 → 297
    TTL; Tubulin-tyrosine ligase family

  13. XM_039113319.2 → XP_038969247.1  tubulin polyglutamylase TTLL5 isoform X9

    UniProtKB/TrEMBL
    A0A8I6GJ32
    Conserved Domains (1) summary
    pfam03133
    Location:1 → 255
    TTL; Tubulin-tyrosine ligase family

  14. XM_039113320.2 → XP_038969248.1  tubulin polyglutamylase TTLL5 isoform X11

    UniProtKB/TrEMBL
    A6JE47
    Conserved Domains (1) summary
    cl17255
    Location:2 → 149
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  15. XM_039113324.2 → XP_038969252.1  tubulin polyglutamylase TTLL5 isoform X13

    UniProtKB/TrEMBL
    A6JE47

  16. XM_039113322.2 → XP_038969250.1  tubulin polyglutamylase TTLL5 isoform X12

    UniProtKB/TrEMBL
    A6JE47

  17. XM_039113323.2 → XP_038969251.1  tubulin polyglutamylase TTLL5 isoform X13

    UniProtKB/TrEMBL
    A6JE47

  18. XM_039113325.2 → XP_038969253.1  tubulin polyglutamylase TTLL5 isoform X14

    UniProtKB/TrEMBL
    A6JE50
Nucleotide Protein Strain
Heading Accession and Version

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