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Asb2 ankyrin repeat and SOCS box-containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299266, updated on 2-Nov-2024

Summary

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Symbol
Asb2provided by RGD
Full Name
ankyrin repeat and SOCS box-containing 2provided by RGD
Primary source
RGD:1306414
See related
EnsemblRapid:ENSRNOG00000051619 AllianceGenome:RGD:1306414
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cullin family protein binding activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in several processes, including heart development; podosome assembly; and skeletal muscle atrophy. Predicted to act upstream of or within skeletal muscle cell differentiation. Predicted to be located in Z disc. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB2 (ankyrin repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 766.4), Heart (RPKM 560.6) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Asb2 in Genome Data Viewer
Location:
6q32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (128239550..128275833, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (122474754..122511014, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (127212325..127248451, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene proline rich membrane anchor 1 Neighboring gene uncharacterized LOC120103607 Neighboring gene family with sequence similarity 181, member A Neighboring gene uncharacterized LOC102549032 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation. Bello NF, et al. Cell Death Differ, 2009 Jun. PMID 19300455, Free PMC Article
  2. ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. Kohroki J, et al. FEBS Lett, 2005 Dec 19. PMID 16325183
  3. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Rajan S, et al. Physiol Genomics, 2012 Feb 1. PMID 22147266
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiac muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendritic cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heart looping ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in podosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle atrophy ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle atrophy ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 2
Names
ASB-2
ankyrin repeat and SOCS box protein 2-like
ankyrin repeat and SOCS box-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011984.1 → NP_001011984.1  ankyrin repeat and SOCS box protein 2

    See identical proteins and their annotated locations for NP_001011984.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085882
    UniProtKB/Swiss-Prot
    Q5U2S6
    UniProtKB/TrEMBL
    A6JEM4
    Related
    ENSRNOP00000071182.1, ENSRNOT00000085517.3
    Conserved Domains (4) summary
    cd00204
    Location:232 → 357
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03721
    Location:590 → 634
    SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...
    pfam12796
    Location:308 → 396
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:237 → 268
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    128239550..128275833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112072.2 → XP_038968000.1  ankyrin repeat and SOCS box protein 2 isoform X2

    Conserved Domains (3) summary
    PHA03095
    Location:199 → 480
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:237 → 268
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:112 → 202
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_063261766.1 → XP_063117836.1  ankyrin repeat and SOCS box protein 2 isoform X1

  3. XM_006240464.5 → XP_006240526.2  ankyrin repeat and SOCS box protein 2 isoform X3

RNA

  1. XR_593075.3 RNA Sequence

    Related
    ENSRNOT00000134554.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2S6.1 GenPept UniProtKB/Swiss-Prot:Q5U2S6

Gene LinkOut

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