Elane elastase, neutrophil expressed [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Elaneprovided by RGD
Official Full Name: elastase, neutrophil expressedprovided by RGD
Primary source: RGD:1307968
See related: EnsemblRapid:ENSRNOG00000033685 AllianceGenome:RGD:1307968
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ela2
Summary: Predicted to enable several functions, including heparin binding activity; serine-type endopeptidase activity; and transcription corepressor activity. Involved in leukocyte migration involved in inflammatory response and positive regulation of leukocyte tethering or rolling. Predicted to be located in cell surface and secretory granule. Predicted to be part of transcription repressor complex. Predicted to be active in extracellular space. Used to study several diseases, including cerebrovascular disease (multiple); lung disease (multiple); mucositis; pleurisy; and polycythemia vera. Biomarker of suppurative periapical periodontitis. Human ortholog(s) of this gene implicated in cyclic hematopoiesis; periodontitis; severe congenital neutropenia; and severe congenital neutropenia 1. Orthologous to human ELANE (elastase, neutrophil expressed). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 51.4) and Thymus (RPKM 13.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10467877..10469725, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9817251..9819174, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12638320..12640168, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neutrophil elastase in dexmedetomidine alleviating sepsis-related renal injury in rats.
Title: Neutrophil elastase in dexmedetomidine alleviating sepsis-related renal injury in rats.
Study provides evidence that an increase in the activity of elastase to cleave PGRN, and to produce GRN, was involved in an inflammatory response at the early stages after cerebral ischemia.
Title: Involvement of Progranulin and Granulin Expression in Inflammatory Responses after Cerebral Ischemia.
Data show that sivelestat decreases neutrophil elastase (NE) expression in sepsis.
Title: The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats.
SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
Title: The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
a new mode of PAR regulation that involves biased PAR(2) signaling by neutrophil elastase and a disarming/silencing effect of cathepsin-G and proteinase-3.
Title: Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2).
we conclude that neutrophil elastase initiated EGFR/MEK/ERK signaling cascade overrides the autocrine TGF-beta signaling on tropoelastin mRNA stability and, therefore, decreases the elastogenic response in RFL-6 fibroblasts [neutrophil elastase]
Title: Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts.
The trafficking of precursor NE (proNE) and precursor PR3 (proPR3), was compared.
Title: Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells.
NE digests ferritin increasing the extracellular iron pool available for cellular uptake
Title: Neutrophil elastase increases airway epithelial nonheme iron levels.
neutrophil elastase might decrease the pulmonary endothelial production of prostacyclin by inhibiting endothelial NO production
Title: Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats.
neutrophil activation by PMA causes release of neutrophil elastase, upregulation of iNOS and MPO, and a series of inflammatory responses leading to endothelial damage and ALI.
Title: The involvement of nitric oxide, nitric oxide synthase, neutrophil elastase, myeloperoxidase and proinflammatory cytokines in the acute lung injury caused by phorbol myristate acetate.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acute inflammatory response to antigenic stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acute inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in biosynthetic process of antibacterial peptides active against Gram-negative bacteria	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to fungus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil-mediated killing of fungus	ISO Inferred from Sequence Orthology more info
involved_in neutrophil-mediated killing of gram-negative bacterium	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in response to UV	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to yeast	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neutrophil elastase

Names: elastase 2, neutrophil

NP_001100237.1

EC 3.4.21.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106767.1 → NP_001100237.1 neutrophil elastase precursor

See identical proteins and their annotated locations for NP_001100237.1

Status: PROVISIONAL

Source sequence(s)

CH474029

UniProtKB/TrEMBL

A6K8V8, D4A488

Related

ENSRNOP00000014981.4, ENSRNOT00000014981.7

Conserved Domains (2) summary

smart00020
Location:32 → 246

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:33 → 249

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...