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Med16 mediator complex subunit 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299607, updated on 2-Nov-2024

Summary

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Official Symbol
Med16provided by RGD
Official Full Name
mediator complex subunit 16provided by RGD
Primary source
RGD:1308001
See related
EnsemblRapid:ENSRNOG00000011315 AllianceGenome:RGD:1308001
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Thrap5
Summary
Predicted to enable nuclear thyroid hormone receptor binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of transcription initiation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED16 (mediator complex subunit 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 65.5), Heart (RPKM 62.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Med16 in Genome Data Viewer
Location:
7q11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10449273..10461797)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9798641..9811172)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12619739..12632241)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene R3H domain containing 4 Neighboring gene U6 spliceosomal RNA Neighboring gene complement factor D Neighboring gene elastase, neutrophil expressed

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. Ito M, et al. EMBO J, 2002 Jul 1. PMID 12093747, Free PMC Article
  2. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. Wang Q, et al. J Biol Chem, 2002 Nov 8. PMID 12218053
  3. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Ito M, et al. Mol Cell, 1999 Mar. PMID 10198638
  4. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article
  5. The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. Kang YK, et al. Proc Natl Acad Sci U S A, 2002 Mar 5. PMID 11867769, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 16
Names
thyroid hormone receptor associated protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106768.1 → NP_001100238.1  mediator of RNA polymerase II transcription subunit 16

    See identical proteins and their annotated locations for NP_001100238.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474029
    UniProtKB/TrEMBL
    A6K8V2, D3ZHA9
    Related
    ENSRNOP00000076087.3, ENSRNOT00000093264.3
    Conserved Domains (4) summary
    smart00320
    Location:95 → 134
    WD40; WD40 repeats
    COG2319
    Location:85 → 280
    WD40; WD40 repeat [General function prediction only]
    pfam11635
    Location:144 → 858
    Med16; Mediator complex subunit 16
    sd00039
    Location:62 → 104
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10449273..10461797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240861.5 → XP_006240923.1  mediator of RNA polymerase II transcription subunit 16 isoform X3

    UniProtKB/TrEMBL
    D3ZHA9
    Conserved Domains (4) summary
    smart00320
    Location:95 → 134
    WD40; WD40 repeats
    COG2319
    Location:85 → 280
    WD40; WD40 repeat [General function prediction only]
    pfam11635
    Location:144 → 886
    Med16; Mediator complex subunit 16
    sd00039
    Location:62 → 104
    7WD40; WD40 repeat [structural motif]

  2. XM_063263165.1 → XP_063119235.1  mediator of RNA polymerase II transcription subunit 16 isoform X5

  3. XM_063263167.1 → XP_063119237.1  mediator of RNA polymerase II transcription subunit 16 isoform X8

  4. XM_006240862.5 → XP_006240924.1  mediator of RNA polymerase II transcription subunit 16 isoform X4

    UniProtKB/TrEMBL
    D3ZHA9
    Conserved Domains (4) summary
    smart00320
    Location:94 → 133
    WD40; WD40 repeats
    COG2319
    Location:84 → 279
    WD40; WD40 repeat [General function prediction only]
    pfam11635
    Location:143 → 885
    Med16; Mediator complex subunit 16
    sd00039
    Location:61 → 103
    7WD40; WD40 repeat [structural motif]

  5. XM_006240864.5 → XP_006240926.1  mediator of RNA polymerase II transcription subunit 16 isoform X6

    UniProtKB/TrEMBL
    D3ZHA9
    Related
    ENSRNOP00000015257.8, ENSRNOT00000015257.8
    Conserved Domains (4) summary
    smart00320
    Location:94 → 133
    WD40; WD40 repeats
    COG2319
    Location:84 → 279
    WD40; WD40 repeat [General function prediction only]
    pfam11635
    Location:143 → 857
    Med16; Mediator complex subunit 16
    sd00039
    Location:61 → 103
    7WD40; WD40 repeat [structural motif]

  6. XM_039078637.2 → XP_038934565.1  mediator of RNA polymerase II transcription subunit 16 isoform X2

    UniProtKB/TrEMBL
    D3ZHA9
    Conserved Domains (3) summary
    smart00320
    Location:59 → 98
    WD40; WD40 repeats
    sd00039
    Location:26 → 68
    7WD40; WD40 repeat [structural motif]
    pfam11635
    Location:108 → 822
    Med16; Mediator complex subunit 16

  7. XM_063263168.1 → XP_063119238.1  mediator of RNA polymerase II transcription subunit 16 isoform X2

    Related
    ENSRNOP00000072279.2, ENSRNOT00000080089.3

  8. XM_063263166.1 → XP_063119236.1  mediator of RNA polymerase II transcription subunit 16 isoform X7

  9. XM_006240865.5 → XP_006240927.1  mediator of RNA polymerase II transcription subunit 16 isoform X7

    See identical proteins and their annotated locations for XP_006240927.1

    UniProtKB/TrEMBL
    A0A0G2K2K5
    Conserved Domains (3) summary
    smart00320
    Location:59 → 98
    WD40; WD40 repeats
    sd00039
    Location:26 → 68
    7WD40; WD40 repeat [structural motif]
    pfam11635
    Location:108 → 850
    Med16; Mediator complex subunit 16

  10. XM_006240866.5 → XP_006240928.1  mediator of RNA polymerase II transcription subunit 16 isoform X7

    See identical proteins and their annotated locations for XP_006240928.1

    UniProtKB/TrEMBL
    A0A0G2K2K5
    Conserved Domains (3) summary
    smart00320
    Location:59 → 98
    WD40; WD40 repeats
    sd00039
    Location:26 → 68
    7WD40; WD40 repeat [structural motif]
    pfam11635
    Location:108 → 850
    Med16; Mediator complex subunit 16

  11. XM_063263164.1 → XP_063119234.1  mediator of RNA polymerase II transcription subunit 16 isoform X1

  12. XM_039078641.2 → XP_038934569.2  mediator of RNA polymerase II transcription subunit 16 isoform X11

  13. XM_063263169.1 → XP_063119239.1  mediator of RNA polymerase II transcription subunit 16 isoform X9

  14. XM_039078640.2 → XP_038934568.1  mediator of RNA polymerase II transcription subunit 16 isoform X10

    Conserved Domains (1) summary
    pfam11635
    Location:14 → 527
    Med16; Mediator complex subunit 16
Nucleotide Protein Strain
Heading Accession and Version

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