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Tmem259 transmembrane protein 259 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299608, updated on 10-Jul-2024

Summary

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Official Symbol
Tmem259provided by RGD
Official Full Name
transmembrane protein 259provided by RGD
Primary source
RGD:1311136
See related
EnsemblRapid:ENSRNOG00000012808 AllianceGenome:RGD:1311136
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mbrl; RGD1311136
Summary
Predicted to be involved in negative regulation of neuron death; positive regulation of ERAD pathway; and response to endoplasmic reticulum stress. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human TMEM259 (transmembrane protein 259). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 181.9), Heart (RPKM 157.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem259 in Genome Data Viewer
Location:
7q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10374804..10381566)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9724196..9730932)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12771239..12777901, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene calponin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene glutamate ionotropic receptor NMDA type subunit 3B Neighboring gene WD repeat domain 18 Neighboring gene AT-rich interaction domain 3A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The critical role of membralin in postnatal motor neuron survival and disease. Yang B, et al. Elife, 2015 May 15. PMID 25977983, Free PMC Article
  2. Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system. Andersson O, et al. Brain Res Gene Expr Patterns, 2002 Oct. PMID 12638133
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. genomic organization and expression (membralin)
    Title: Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membralin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100886.1 → NP_001094356.1  membralin

    Status: VALIDATED

    Source sequence(s)
    BC100259, CK843921
    UniProtKB/TrEMBL
    F1LPC5, Q498D7
    Related
    ENSRNOP00000017245.6, ENSRNOT00000017245.8
    Conserved Domains (2) summary
    pfam09746
    Location:34 → 393
    Membralin; tumor-associated protein
    cl41730
    Location:455 → 572
    KLF9_13_N-like; Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10374804..10381566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078642.2 → XP_038934570.1  membralin isoform X1

    UniProtKB/TrEMBL
    A0A8I6A0I0
    Related
    ENSRNOP00000084057.1, ENSRNOT00000111728.2
    Conserved Domains (2) summary
    pfam09746
    Location:34 → 417
    Membralin; tumor-associated protein
    cl41730
    Location:479 → 596
    KLF9_13_N-like; Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins

  2. XM_006240869.5 → XP_006240931.1  membralin isoform X2

    UniProtKB/TrEMBL
    Q498D7
    Conserved Domains (1) summary
    pfam09746
    Location:34 → 376
    Membralin; Tumour-associated protein

  3. XM_006240870.5 → XP_006240932.1  membralin isoform X3

    UniProtKB/TrEMBL
    Q498D7
    Conserved Domains (1) summary
    pfam09746
    Location:34 → 365
    Membralin; Tumour-associated protein
Nucleotide Protein Strain
Heading Accession and Version

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