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Gadd45b growth arrest and DNA-damage-inducible, beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 299626, updated on 2-Nov-2024

Summary

Official Symbol
Gadd45bprovided by RGD
Official Full Name
growth arrest and DNA-damage-inducible, betaprovided by RGD
Primary source
RGD:1309080
See related
EnsemblRapid:ENSRNOG00000019822 AllianceGenome:RGD:1309080
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in positive regulation of MAPK cascade; positive regulation of apoptotic process; and regulation of cell cycle. Predicted to act upstream of or within negative regulation of protein kinase activity and positive regulation of MAPK cascade. Predicted to be active in cytoplasm and nucleus. Orthologous to human GADD45B (growth arrest and DNA damage inducible beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 121.0), Spleen (RPKM 63.1) and 9 other tissues See more
Orthologs
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Genomic context

See Gadd45b in Genome Data Viewer
Location:
7q11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9428689..9430991, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8778004..8780306, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11646283..11648338, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 7 Neighboring gene uncharacterized LOC102553301 Neighboring gene transfer RNA proline (anticodon AGG) 48 Neighboring gene uncharacterized LOC134479806 Neighboring gene lamin B2 Neighboring gene translocase of inner mitochondrial membrane 13

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC105966

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
growth arrest and DNA damage-inducible protein GADD45 beta
Names
growth arrest and DNA-damage-inducible 45 beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008321.1NP_001008322.1  growth arrest and DNA damage-inducible protein GADD45 beta

    See identical proteins and their annotated locations for NP_001008322.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085337
    UniProtKB/TrEMBL
    F7FLQ8, Q5U3Z2
    Related
    ENSRNOP00000026871.2, ENSRNOT00000026871.6
    Conserved Domains (1) summary
    pfam01248
    Location:21120
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9428689..9430991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240888.5XP_006240950.1  growth arrest and DNA damage-inducible protein GADD45 beta isoform X1

    Conserved Domains (1) summary
    pfam01248
    Location:21120
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family