U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299739, updated on 2-Nov-2024

Summary

Symbol
Ndufa12provided by RGD
Full Name
NADH:ubiquinone oxidoreductase subunit A12provided by RGD
Primary source
RGD:1311462
See related
EnsemblRapid:ENSRNOG00000007407 AllianceGenome:RGD:1311462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311462
Summary
Predicted to be involved in mitochondrial ATP synthesis coupled electron transport and response to oxidative stress. Predicted to be located in cytosol and mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 23. Orthologous to human NDUFA12 (NADH:ubiquinone oxidoreductase subunit A12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 2939.1), Muscle (RPKM 1716.2) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ndufa12 in Genome Data Viewer
Location:
7q13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (30658316..30685302)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (28771330..28798316)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (35125516..35163182)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene nuclear receptor subfamily 2, group C, member 1 Neighboring gene U4 spliceosomal RNA Neighboring gene transmembrane and coiled-coil domain family 3 Neighboring gene uncharacterized LOC102554269 Neighboring gene uncharacterized LOC134479860

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mitochondrial ATP synthesis coupled electron transport ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial respiratory chain complex I assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12-like
NP_001100251.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106781.2NP_001100251.2  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

    See identical proteins and their annotated locations for NP_001100251.2

    Status: VALIDATED

    Source sequence(s)
    BF555697, BG671355, BQ205274
    UniProtKB/TrEMBL
    A6IG10, F1LXA0
    Related
    ENSRNOP00000010117.7, ENSRNOT00000010117.7
    Conserved Domains (1) summary
    pfam05071
    Location:37137
    NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    30658316..30685302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)