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Cnot2 CCR4-NOT transcription complex, subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299805, updated on 13-Apr-2024

Summary

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Official Symbol
Cnot2provided by RGD
Official Full Name
CCR4-NOT transcription complex, subunit 2provided by RGD
Primary source
RGD:1311672
See related
Ensembl:ENSRNOG00000004909 AllianceGenome:RGD:1311672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transcription corepressor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Predicted to be involved in several processes, including negative regulation of cellular macromolecule biosynthetic process; negative regulation of intracellular estrogen receptor signaling pathway; and positive regulation of cytoplasmic mRNA processing body assembly. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 397.7), Kidney (RPKM 240.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (54016447..54117511, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52130445..52222338, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (59526105..59617307, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, B Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 4 Neighboring gene protein disulfide isomerase family A, member 4, pseudogene 1 Neighboring gene uncharacterized LOC120093596

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death. Ito K, et al. Genes Cells, 2011 Apr. PMID 21299754
  2. Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex. Zwartjes CG, et al. J Biol Chem, 2004 Mar 19. PMID 14707134
  3. Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. Jayne S, et al. Biochem J, 2006 Sep 15. PMID 16712523, Free PMC Article
  4. Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. Zheng X, et al. Stem Cells, 2012 May. PMID 22367759, Free PMC Article
  5. RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes. Wahle E, et al. Biochim Biophys Acta, 2013 Jun-Jul. PMID 23337855

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytoplasmic mRNA processing body assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of stem cell population maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in trophectodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
  
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CCR4-NOT transcription complex subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399553.1 → NP_001386482.1  CCR4-NOT transcription complex subunit 2 Isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I5Y9U2
    Related
    ENSRNOP00000077944.1, ENSRNOT00000114739.1

  2. NM_001399554.1 → NP_001386483.1  CCR4-NOT transcription complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  3. NM_001399555.1 → NP_001386484.1  CCR4-NOT transcription complex subunit 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2KB82

  4. NM_001399556.1 → NP_001386485.1  CCR4-NOT transcription complex subunit 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6IGP1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    54016447..54117511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078732.2 → XP_038934660.1  CCR4-NOT transcription complex subunit 2 isoform X8

    UniProtKB/TrEMBL
    A6IGN0
    Conserved Domains (1) summary
    pfam04153
    Location:228 → 351
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  2. XM_006241369.4 → XP_006241431.1  CCR4-NOT transcription complex subunit 2 isoform X3

    See identical proteins and their annotated locations for XP_006241431.1

    UniProtKB/TrEMBL
    A0A8I6AJD1
    Conserved Domains (1) summary
    pfam04153
    Location:365 → 488
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  3. XM_039078728.2 → XP_038934656.1  CCR4-NOT transcription complex subunit 2 isoform X6

    UniProtKB/TrEMBL
    A6IGN1
    Conserved Domains (1) summary
    pfam04153
    Location:269 → 392
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  4. XM_039078720.2 → XP_038934648.1  CCR4-NOT transcription complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2KB82, A0A8I6AJD1
    Conserved Domains (1) summary
    pfam04153
    Location:387 → 510
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  5. XM_017594741.3 → XP_017450230.1  CCR4-NOT transcription complex subunit 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZXR1, A6IGN2
    Related
    ENSRNOP00000084380.1
    Conserved Domains (1) summary
    pfam04153
    Location:355 → 478
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  6. XM_039078730.2 → XP_038934658.1  CCR4-NOT transcription complex subunit 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZKS1, A6IGN1
    Related
    ENSRNOP00000078367.1
    Conserved Domains (1) summary
    pfam04153
    Location:259 → 382
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  7. XM_039078717.2 → XP_038934645.1  CCR4-NOT transcription complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AJD1
    Conserved Domains (1) summary
    pfam04153
    Location:396 → 519
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  8. XM_063263224.1 → XP_063119294.1  CCR4-NOT transcription complex subunit 2 isoform X5

    UniProtKB/TrEMBL
    A6IGP0

  9. XM_039078735.2 → XP_038934663.1  CCR4-NOT transcription complex subunit 2 isoform X11

    UniProtKB/TrEMBL
    A6IGP2
    Conserved Domains (1) summary
    pfam04153
    Location:136 → 259
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  10. XM_063263225.1 → XP_063119295.1  CCR4-NOT transcription complex subunit 2 isoform X9

  11. XM_063263226.1 → XP_063119296.1  CCR4-NOT transcription complex subunit 2 isoform X10

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001011988.2: Suppressed sequence

    Description
    NM_001011988.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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