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Dscc1 DNA replication and sister chromatid cohesion 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299933, updated on 2-Nov-2024

Summary

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Official Symbol
Dscc1provided by RGD
Official Full Name
DNA replication and sister chromatid cohesion 1provided by RGD
Primary source
RGD:1561749
See related
EnsemblRapid:ENSRNOG00000026502 AllianceGenome:RGD:1561749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561749
Summary
Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in maintenance of mitotic sister chromatid cohesion; positive regulation of DNA-directed DNA polymerase activity; and post-translational protein acetylation. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of Ctf18 RFC-like complex. Predicted to be active in chromosome, centromeric region. Orthologous to human DSCC1 (DNA replication and sister chromatid cohesion 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 69.4), Spleen (RPKM 47.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dscc1 in Genome Data Viewer
Location:
7q32
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (88372349..88390815, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (86482588..86498212, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (94759076..94774787, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093657 Neighboring gene TATA-box binding protein associated factor 2 Neighboring gene uncharacterized LOC134479906 Neighboring gene large ribosomal subunit protein uL30-like Neighboring gene H3 histone, family 3C Neighboring gene DEP domain containing MTOR-interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cohesin acetylation speeds the replication fork. Terret ME, et al. Nature, 2009 Nov 12. PMID 19907496, Free PMC Article
  2. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. Bermudez VP, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12930902, Free PMC Article
  3. Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Watrin E, et al. Curr Biol, 2006 May 9. PMID 16682347
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to DNA clamp loader activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to single-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in post-translational protein acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ctf18 RFC-like complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sister chromatid cohesion protein DCC1
Names
defective in sister chromatid cohesion 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305236.1 → NP_001292165.1  sister chromatid cohesion protein DCC1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    D4ACA3
    Related
    ENSRNOP00000105245.1, ENSRNOT00000163367.1
    Conserved Domains (1) summary
    pfam09724
    Location:49 → 363
    Dcc1; Sister chromatid cohesion protein Dcc1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    88372349..88390815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263252.1 → XP_063119322.1  sister chromatid cohesion protein DCC1 isoform X2

    Related
    ENSRNOP00000108651.1, ENSRNOT00000125966.1

  2. XM_039078787.2 → XP_038934715.1  sister chromatid cohesion protein DCC1 isoform X3

    UniProtKB/TrEMBL
    A6HRG8
    Conserved Domains (1) summary
    pfam09724
    Location:58 → 326
    Dcc1; Sister chromatid cohesion protein Dcc1

  3. XM_039078786.2 → XP_038934714.1  sister chromatid cohesion protein DCC1 isoform X1

    UniProtKB/TrEMBL
    A6HRG8
    Conserved Domains (1) summary
    pfam09724
    Location:58 → 372
    Dcc1; Sister chromatid cohesion protein Dcc1

  4. XM_039078788.2 → XP_038934716.1  sister chromatid cohesion protein DCC1 isoform X4

    Conserved Domains (1) summary
    pfam09724
    Location:58 → 208
    Dcc1; Sister chromatid cohesion protein Dcc1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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