Amigo2 adhesion molecule with Ig like domain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Amigo2provided by RGD
Official Full Name: adhesion molecule with Ig like domain 2provided by RGD
Primary source: RGD:727911
See related: EnsemblRapid:ENSRNOG00000007032 AllianceGenome:RGD:727911
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ali1
Summary: Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and negative regulation of neuron apoptotic process. Located in nucleus and plasma membrane. Orthologous to human AMIGO2 (adhesion molecule with Ig like domain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 296.5), Heart (RPKM 69.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (130270639..130273735, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (128391493..128394589, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (138704124..138707221, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IPI Inferred from Physical Interaction more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: amphoterin-induced protein 2

Names: AMIGO-2; alivin 1; amphoterin induced gene 2; transmembrane protein AMIGO2; transmembrane protein AMIGO2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182816.3 → NP_877968.3 amphoterin-induced protein 2 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q7TNJ4, Q80ZD6

UniProtKB/TrEMBL

A0A0G2JSI9, A6KC34

Conserved Domains (6) summary

COG4886
Location:53 → 240

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:219 → 231

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:50 → 71

LRR_RI; leucine-rich repeat [structural motif]

pfam00047
Location:297 → 367

ig; Immunoglobulin domain

pfam13855
Location:93 → 174

LRR_8; Leucine rich repeat

cd00096
Location:304 → 312

Ig; Ig strand B [structural motif]