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Lmbr1l limb development membrane protein 1-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 300215, updated on 10-Jul-2024

Summary

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Official Symbol
Lmbr1lprovided by RGD
Official Full Name
limb development membrane protein 1-likeprovided by RGD
Primary source
RGD:1309631
See related
EnsemblRapid:ENSRNOG00000061607 AllianceGenome:RGD:1309631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309631
Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in several processes, including T cell activation; hematopoietic stem cell differentiation; and negative regulation of canonical Wnt signaling pathway. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human LMBR1L (limb development membrane protein 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 107.0), Testes (RPKM 87.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lmbr1l in Genome Data Viewer
Location:
7q36
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131940081..131958832, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130061136..130078101, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140585512..140600797, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C Neighboring gene RHEB like 1 Neighboring gene ribosomal protein L13, pseudogene 3 Neighboring gene desert hedgehog signaling molecule Neighboring gene tubulin, alpha 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lipocalin-interacting-membrane-receptor (LIMR) mediates cellular internalization of beta-lactoglobulin. Fluckinger M, et al. Biochim Biophys Acta, 2008 Jan. PMID 17991420
  2. Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells. Wojnar P, et al. J Biol Chem, 2003 May 2. PMID 12591932
  3. Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display. Wojnar P, et al. J Biol Chem, 2001 Jun 8. PMID 11287427
  4. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Choi JH, et al. Science, 2019 May 10. PMID 31073040, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109220

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein LMBR1L
Names
limb region 1 like
limb region 1-like homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013950.1 → NP_001013972.1  protein LMBR1L isoform 2

    See identical proteins and their annotated locations for NP_001013972.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089929
    UniProtKB/TrEMBL
    F1MAN0, Q5FVK3
    Conserved Domains (1) summary
    pfam04791
    Location:28 → 220
    LMBR1; LMBR1-like membrane protein

  2. NM_001395729.1 → NP_001382658.1  protein LMBR1L isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2JVJ7
    Related
    ENSRNOP00000069512.1, ENSRNOT00000082375.3
    Conserved Domains (1) summary
    pfam04791
    Location:21 → 452
    LMBR1; LMBR1-like membrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    131940081..131958832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078924.2 → XP_038934852.1  protein LMBR1L isoform X4

    Conserved Domains (1) summary
    pfam04791
    Location:32 → 421
    LMBR1; LMBR1-like membrane protein

  2. XM_039078922.2 → XP_038934850.1  protein LMBR1L isoform X1

    Conserved Domains (1) summary
    pfam04791
    Location:21 → 456
    LMBR1; LMBR1-like membrane protein

  3. XM_017594788.3 → XP_017450277.1  protein LMBR1L isoform X2

    Conserved Domains (1) summary
    pfam04791
    Location:28 → 450
    LMBR1; LMBR1-like membrane protein

  4. XM_039078923.2 → XP_038934851.1  protein LMBR1L isoform X3

    Conserved Domains (1) summary
    pfam04791
    Location:21 → 456
    LMBR1; LMBR1-like membrane protein

  5. XM_063263379.1 → XP_063119449.1  protein LMBR1L isoform X5

    Related
    ENSRNOP00000099174.1, ENSRNOT00000156677.1

  6. XM_039078925.2 → XP_038934853.1  protein LMBR1L isoform X6

    Conserved Domains (1) summary
    pfam04791
    Location:1 → 329
    LMBR1; LMBR1-like membrane protein
Nucleotide Protein Strain
Heading Accession and Version

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