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Dazap2 DAZ associated protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300235, updated on 2-Nov-2024

Summary

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Official Symbol
Dazap2provided by RGD
Official Full Name
DAZ associated protein 2provided by RGD
Primary source
RGD:1307407
See related
EnsemblRapid:ENSRNOG00000004628 AllianceGenome:RGD:1307407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including WW domain binding activity; enzyme binding activity; and p53 binding activity. Predicted to be involved in protein destabilization and stress granule assembly. Predicted to be located in cytoplasmic stress granule and nuclear speck. Predicted to be part of protein-containing complex. Orthologous to human DAZAP2 (DAZ associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 1223.0), Heart (RPKM 1012.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dazap2 in Genome Data Viewer
Location:
7q36
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133593503..133599044)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131714749..131720266)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142238780..142244301)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479579 Neighboring gene uncharacterized LOC134479580 Neighboring gene small cell adhesion glycoprotein Neighboring gene bridging integrator 2 Neighboring gene uncharacterized LOC134479578 Neighboring gene chymotrypsin like elastase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. Hamilton MH, et al. J Biol Chem, 2001 Jul 13. PMID 11342538
  2. Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling. Winkel A, et al. Cell Signal, 2008 Nov. PMID 18762249
  3. Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1. Tsui S, et al. Genomics, 2000 May 1. PMID 10857750
  4. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
  5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables p53 binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein destabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DAZ-associated protein 2
Names
deleted in azoospermia-associated protein 2
proline-rich transcript in brain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395672.1 → NP_001382601.1  DAZ-associated protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    A0A0H2UHD1, P60486
    Conserved Domains (1) summary
    pfam11029
    Location:35 → 168
    DAZAP2; DAZ associated protein 2 (DAZAP2)

  2. NM_001395673.1 → NP_001382602.1  DAZ-associated protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    Conserved Domains (1) summary
    pfam11029
    Location:1 → 108
    DAZAP2; DAZ associated protein 2 (DAZAP2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    133593503..133599044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078934.2 → XP_038934862.1  DAZ-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A0A0H2UHD1, P60486
    Related
    ENSRNOP00000006239.6, ENSRNOT00000006239.9
    Conserved Domains (1) summary
    pfam11029
    Location:35 → 168
    DAZAP2; DAZ associated protein 2 (DAZAP2)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013107.1: Suppressed sequence

    Description
    NM_001013107.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60486.2 GenPept UniProtKB/Swiss-Prot:P60486

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
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